UBA1 and MGMT

Number of citations of the paper that reports this interaction (PubMedID 8573590)
0

Data Source:
HPRD (in vitro, in vivo)

		UBA1	MGMT
Description		ubiquitin like modifier activating enzyme 1	O-6-methylguanine-DNA methyltransferase
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Nucleus Nucleoplasm Membrane
	Molecular Function	Nucleotide Binding RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity	DNA Binding Catalytic Activity Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Methyltransferase Activity DNA-methyltransferase Activity Transferase Activity Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination	DNA Repair DNA Alkylation Repair DNA Damage Response Methylation Negative Regulation Of Apoptotic Process Positive Regulation Of Double-strand Break Repair
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	MGMT-mediated DNA damage reversal
Drugs		Hexatantalum Dodecabromide Quercetin	Cysteine Zinc S-Methylcysteine S-Benzylcysteine Dinitrochlorobenzene Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Adult body size ( 32376654) Alzheimer's disease in APOE e4- carriers ( 25778476) Anorexia nervosa ( 31308545) Chronotype ( 30696823) Drug experimentation measurement ( 30718321) Gut microbiota (functional units) ( 27694959) Hand grip strength ( 29691431 29313844) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Lead levels ( 26025379) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) MGMT methylation in smokers ( 26183928) Modic changes ( 30808802) Response to temozolomide ( 23047291) Tea consumption ( 31046077) Triglyceride levels in HIV infection ( 33109212) Waist-to-hip circumference ratio (ever vs never smoking interaction) ( 23192594)
Interacting Genes		51 interacting genes: ABCF1 AZGP1P2 BUB3 CDK1 CEBPA CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2	10 interacting genes: BCL2L13 CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 PCNA PRKACA PRKCA UBA1
Entrez ID		7317	4255
HPRD ID		02440	01135
Ensembl ID		ENSG00000130985	ENSG00000170430
Uniprot IDs		A0A024R1A3 P22314	B4DEE8 P16455
PDB IDs		4P22 6DC6 7PYV	1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH 8RGG 8RGH 8RTY 8RU2
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein Modification Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Ubiquitin-dependent Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Nucleoplasm ISG15 Transferase Activity HULC Complex DNA Damage Response ISG15-protein Conjugation Regulation Of Post-translational Protein Modification Free Ubiquitin Chain Polymerization Nucleus DNA Repair Positive Regulation Of Post-translational Protein Modification Protein K29-linked Ubiquitination Cellular Response To Stress Cell Cycle Phase Transition Ubiquitin Binding Regulation Of Protein Modification Process Protein K27-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination TORC1 Signaling DNA Metabolic Process	Histone H3K18 Acetyltransferase Activity Rhythmic Process N-terminal Peptidyl-lysine Acetylation Cellular Response To Stress Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Protein Kinase CK2 Complex Prostate Epithelial Cord Elongation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Damage Response Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Damaged DNA Binding Response To Stress Cell Death Apoptotic Process Protein Kinase Activity Programmed Cell Death Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Prostate Gland Growth Nucleus Cellular Response To UV Nucleobase-containing Compound Metabolic Process Regulation Of Smoothened Signaling Pathway Macromolecule Metabolic Process Transferase Activity N-terminal Protein Amino Acid Acetylation Kinase Activity Response To Hormone Branching Involved In Prostate Gland Morphogenesis Peptidyl-lysine Acetylation Branch Elongation Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Regulation Of Cellular Response To Heat Cellular Response To Light Stimulus Protein Localization To Chromosome Response To Estradiol Protein Serine Kinase Activity Axis Elongation Acetyltransferase Activity Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Autophagy Negative Regulation Of Catabolic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Protein Serine/threonine Kinase Activity
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