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UBA1 and UBE2E1
Number of citations of the paper that reports this interaction (PubMedID
37558718
)
87
Data Source:
BioGRID
(enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down)
UBA1
UBE2E1
Description
ubiquitin like modifier activating enzyme 1
ubiquitin conjugating enzyme E2 E1
Image
GO Annotations
Cellular Component
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosomal Membrane
Cytosol
Endosome Membrane
Desmosome
Rough Endoplasmic Reticulum Membrane
Extracellular Exosome
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Nucleotide Binding
RNA Binding
Ubiquitin Activating Enzyme Activity
Protein Binding
ATP Binding
Ubiquitin-like Modifier Activating Enzyme Activity
Ligase Activity
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
ISG15 Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response
Protein Ubiquitination
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Negative Regulation Of Gene Expression
Protein Ubiquitination
ISG15-protein Conjugation
Positive Regulation Of Transcription By RNA Polymerase II
Protein K48-linked Ubiquitination
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
ISG15 antiviral mechanism
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Hexatantalum Dodecabromide
Quercetin
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Academic attainment (English) (
33594131
)
Acne (severe) (
24927181
)
Extremely high intelligence (
29520040
)
Metabolite levels (
23823483
)
Interacting Genes
51 interacting genes:
ABCF1
AZGP1P2
BUB3
CDK1
CEBPA
CHEK1
ECHS1
GAN
GRB2
HGS
HSPH1
LINC01554
MGMT
MTNR1A
OGT
PIAS3
SEMA3F
SMAD5
SUMO2
TAF9
TMCC2
TSSC4
TTC19
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2J1
UBE2J2
UBE2K
UBE2L1
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2Q2
UBE2R2
UBE2S
UBE2T
UBE2U
UBE2W
UBE2Z
UBTD2
116 interacting genes:
ARIH2
ARK2C
ASXL2
BARD1
BIRC7
BIRC8
BRCA1
CADPS2
CBL
CHFR
CNOT4
CUL3
DTX1
DTX3
DTX3L
DZIP3
EPS15
F12
FBXO2
FBXO7
HDAC6
IPO11
ITCH
JADE1
LRSAM1
MAP3K1
MARCHF2
MARCHF3
MARCHF5
MARCHF7
MDM2
MGRN1
MID1
MKRN3
MUL1
NEDD4
NEDD4L
NHLRC1
PAEP
PBX2
POLL
POLM
PRKN
RBX1
RELA
RFWD3
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF128
RNF13
RNF130
RNF14
RNF150
RNF152
RNF166
RNF167
RNF168
RNF169
RNF181
RNF185
RNF2
RNF20
RNF26
RNF31
RNF34
RNF4
RNF43
RNF5
RNF8
STUB1
TOPORS
TRAF6
TRIM13
TRIM17
TRIM2
TRIM21
TRIM23
TRIM27
TRIM28
TRIM29
TRIM3
TRIM32
TRIM33
TRIM37
TRIM38
TRIM39
TRIM45
TRIM50
TRIM69
TRIM7
UBA1
UBA6
UBA7
UBASH3B
UBC
UBE2G1
UBE3A
UBOX5
UBR5
UBR7
UFM1
USP7
UVSSA
WWP2
XIAP
ZNG1E
ZNRF1
ZNRF2
ZNRF4
Entrez ID
7317
7324
HPRD ID
02440
04225
Ensembl ID
ENSG00000130985
ENSG00000170142
Uniprot IDs
A0A024R1A3
P22314
B7Z306
P51965
PDB IDs
4P22
6DC6
7PYV
1XR9
3BZH
4JJQ
5LBN
6FGA
8IYA
Enriched GO Terms of Interacting Partners
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Ubiquitin Conjugating Enzyme Activity
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Ubiquitination
Protein K48-linked Ubiquitination
Ubiquitin-like Protein Transferase Activity
Protein Modification Process
Protein K11-linked Ubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
ATP Binding
Transferase Activity
Ubiquitin-dependent Protein Catabolic Process
Nucleotide Binding
Protein Metabolic Process
Macromolecule Catabolic Process
Proteolysis
Ubiquitin Protein Ligase Binding
Protein Monoubiquitination
Macromolecule Metabolic Process
Catabolic Process
Protein K63-linked Ubiquitination
Proteasomal Protein Catabolic Process
Protein K6-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Nucleoplasm
ISG15 Transferase Activity
HULC Complex
DNA Damage Response
ISG15-protein Conjugation
Regulation Of Post-translational Protein Modification
Free Ubiquitin Chain Polymerization
Nucleus
DNA Repair
Positive Regulation Of Post-translational Protein Modification
Protein K29-linked Ubiquitination
Cellular Response To Stress
Cell Cycle Phase Transition
Ubiquitin Binding
Regulation Of Protein Modification Process
Protein K27-linked Ubiquitination
Positive Regulation Of Protein Ubiquitination
Ubiquitin Ligase Complex
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Ubiquitination
TORC1 Signaling
DNA Metabolic Process
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Protein Polyubiquitination
Transferase Activity
Protein Metabolic Process
Zinc Ion Binding
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Proteolysis
Metal Ion Binding
Macromolecule Metabolic Process
Protein Autoubiquitination
Catabolic Process
Protein K48-linked Ubiquitination
Protein K63-linked Ubiquitination
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Ubiquitin Ligase Complex
Cellular Response To Stress
Ubiquitin Protein Ligase Binding
Response To Stress
Regulation Of Post-translational Protein Modification
Cytoplasm
Positive Regulation Of Catabolic Process
Ubiquitin Binding
Positive Regulation Of Post-translational Protein Modification
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Autophagy
DNA Damage Response
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Ubiquitination
Protein K6-linked Ubiquitination
Negative Regulation Of Signal Transduction
Innate Immune Response
Regulation Of Signal Transduction
Immune System Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Protein Catabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
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Tagcloud (Intersection)
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