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UBA1 and UBE2B
Number of citations of the paper that reports this interaction (PMID
17597759
)
66
Data Source:
BioGRID
(enzymatic study, pull down)
UBA1
UBE2B
Gene Name
ubiquitin-like modifier activating enzyme 1
ubiquitin-conjugating enzyme E2B
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Heterochromatin
Nucleus
Cytoplasm
Mitochondrion
Lysosomal Membrane
Cytosol
Endosome Membrane
Desmosome
Rough Endoplasmic Reticulum Membrane
Extracellular Vesicular Exosome
Chromatin
Nuclear Chromatin
XY Body
Nucleus
Replication Fork
Cytoplasm
Plasma Membrane
HULC Complex
Molecular Function
Ubiquitin Activating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Poly(A) RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Biological Process
Cellular Response To DNA Damage Stimulus
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Protein Polyubiquitination
Response To Hypoxia
In Utero Embryonic Development
DNA Repair
Postreplication Repair
Maintenance Of Chromatin Silencing
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Sperm Axoneme Assembly
Response To UV
Positive Regulation Of Reciprocal Meiotic Recombination
Protein Ubiquitination
Cellular Response To Insulin Stimulus
Negative Regulation Of Histone Phosphorylation
Histone H2A Ubiquitination
Response To Drug
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of CAMP-mediated Signaling
Protein Stabilization
Chiasma Assembly
Protein Autoubiquitination
Canonical Wnt Signaling Pathway
Histone Lysine Demethylation
Synaptonemal Complex Organization
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
39 interactors:
BUB3
CDC34
CDK1
CREB3L1
CREB3L2
ECHS1
GAN
GRB2
HGS
HSPH1
MGMT
PIAS3
SEMA3F
SMAD5
TAF9
TMCC2
TSSC4
TTC19
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2K
UBE2L3
UBE2R2
UBE2S
UBE2T
UBE2W
UBTD2
19 interactors:
BIRC2
CDKN1B
CNOT4
CRMP1
CTNNB1
HIST2H2AC
MED31
PCNA
RAD18
RNF20
RNF40
TRIM45
UBA1
UBC
UBR1
UBR2
UBR3
UBR5
UNC119
Entrez ID
7317
7320
HPRD ID
02440
01533
Ensembl ID
ENSG00000130985
ENSG00000119048
Uniprot IDs
P22314
P63146
PDB IDs
1JAS
1NXA
2Y4W
2YB6
2YBF
Enriched GO Terms of Interacting Partners
?
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein K11-linked Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Cellular Protein Modification Process
Proteolysis
Catabolic Process
Cellular Protein Metabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Protein K63-linked Ubiquitination
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Protein Monoubiquitination
Cellular Response To Stress
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Protein Ubiquitination
Cellular Metabolic Process
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Cellular Response To DNA Damage Stimulus
Response To Organic Substance
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Proteasomal Protein Catabolic Process
MyD88-independent Toll-like Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Toll-like Receptor 3 Signaling Pathway
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Mitotic Cell Cycle Checkpoint
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cell Cycle Process
Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Chromosome Organization
Spindle Assembly Checkpoint
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Cellular Response To Leucine
Proteolysis
Histone Ubiquitination
Cellular Protein Modification Process
Regulation Of Protein K63-linked Ubiquitination
Protein Polyubiquitination
Response To Cadmium Ion
Response To Leucine
Histone H2B Ubiquitination
Cellular Response To DNA Damage Stimulus
Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Response To Amino Acid
Cell Cycle Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Cellular Protein Metabolic Process
Histone Monoubiquitination
Regulation Of Histone Modification
Response To Abiotic Stimulus
Positive Regulation Of Cellular Protein Metabolic Process
Protein Metabolic Process
Positive Regulation Of Wnt Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of TOR Signaling
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Organonitrogen Compound
Positive Regulation Of Histone Methylation
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Chromosome Organization
Negative Regulation Of Protein Metabolic Process
Protein Monoubiquitination
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Modification Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Cellular Metabolic Process
Tagcloud
?
aspect
bax
box
caspases
consisting
counterpart
debcl
degrading
documented
drosophila
e3
fruitfly
homologue
iaps
identifies
involve
ligase
modifier
multimeric
proteasome
proteolytic
regulators
scf
screen
shed
slimb
stimulates
trcp
ubiquitin
Tagcloud (Difference)
?
aspect
bax
box
caspases
consisting
counterpart
debcl
degrading
documented
drosophila
e3
fruitfly
homologue
iaps
identifies
involve
ligase
modifier
multimeric
proteasome
proteolytic
regulators
scf
screen
shed
slimb
stimulates
trcp
ubiquitin
Tagcloud (Intersection)
?