UBA1 and GAN

Number of citations of the paper that reports this interaction (PubMedID 16227972)
0

Data Source:
HPRD (two hybrid)

		UBA1	GAN
Description		ubiquitin like modifier activating enzyme 1	gigaxonin
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination	Cytoskeleton Organization Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Hexatantalum Dodecabromide Quercetin
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Age-related cataracts ( 25352737) Health literacy ( 31250787) Post bronchodilator FEV1 ( 26634245) Skin and soft tissue infections ( 33662382) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		51 interacting genes: ABCF1 AZGP1P2 BUB3 CDK1 CEBPA CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2	4 interacting genes: ATG16L1 MAP1B TBCB UBA1
Entrez ID		7317	8139
HPRD ID		02440	05647
Ensembl ID		ENSG00000130985	ENSG00000261609
Uniprot IDs		A0A024R1A3 P22314	A0A0S2Z4W2 B3KTC3 Q9H2C0
PDB IDs		4P22 6DC6 7PYV	2PPI 3HVE
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein Modification Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Ubiquitin-dependent Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Nucleoplasm ISG15 Transferase Activity HULC Complex DNA Damage Response ISG15-protein Conjugation Regulation Of Post-translational Protein Modification Free Ubiquitin Chain Polymerization Nucleus DNA Repair Positive Regulation Of Post-translational Protein Modification Protein K29-linked Ubiquitination Cellular Response To Stress Cell Cycle Phase Transition Ubiquitin Binding Regulation Of Protein Modification Process Protein K27-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination TORC1 Signaling DNA Metabolic Process	Induction Of Synaptic Plasticity By Chemical Substance Vacuole-isolation Membrane Contact Site Post-chaperonin Tubulin Folding Pathway Tubulin Complex Assembly Microtubule-based Process Cytosol Autophagy Plasmacytoid Dendritic Cell Activation Plasmacytoid Dendritic Cell Differentiation Follicular B Cell Differentiation Germinal Center B Cell Differentiation Positive Regulation Of Synaptic Plasticity Varicosity Cell Projection Morphogenesis Response To Insecticide Peripheral Nervous System Axon Regeneration Microtubule-based Transport Odontoblast Differentiation Transport Along Microtubule Neuron Projection Morphogenesis Hippocampal Mossy Fiber Cytoskeleton-dependent Intracellular Transport Basal Dendrite Endosome Membrane Rough Endoplasmic Reticulum Membrane Ubiquitin-like Modifier Activating Enzyme Activity Ubiquitin Activating Enzyme Activity C-terminal Protein Lipidation Viral RNA Genome Replication Xenophagy Negative Regulation Of Dendrite Extension Negative Stranded Viral RNA Replication Atg12-Atg5-Atg16 Complex Regulation Of Developmental Growth Dendrite Arborization Microtubule Response To Vitamin A Response To Stress Apical Dendrite Somatodendritic Compartment Microtubule-based Movement Lysosomal Membrane Protein Localization To Phagophore Assembly Site Regulation Of Cell Growth Axon Corpus Callosum Development Endolysosome Membrane Ubiquitin-like Protein Transferase Activity Neuron Projection Arborization Viral Genome Replication
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