UBA1 and ABCF1

Number of citations of the paper that reports this interaction (PubMedID 30770245)
0

Data Source:
BioGRID (enzymatic study)

		UBA1	ABCF1
Description		ubiquitin like modifier activating enzyme 1	ATP binding cassette subfamily F member 1
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Nucleotide Binding RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity	Nucleotide Binding RNA Binding Protein Binding ATP Binding Translation Factor Activity, RNA Binding Translation Activator Activity ATP Hydrolysis Activity Ribosome Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination	Translation Translational Initiation Inflammatory Response Ribosome Biogenesis Positive Regulation Of Translation
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	ABC-family proteins mediated transport
Drugs		Hexatantalum Dodecabromide Quercetin
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) General cognitive ability ( 29844566) IgM levels ( 28628107) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		51 interacting genes: ABCF1 AZGP1P2 BUB3 CDK1 CEBPA CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2	6 interacting genes: APP CEBPA EIF6 LCOR SUMO2 UBA1
Entrez ID		7317	23
HPRD ID		02440	09139
Ensembl ID		ENSG00000130985	ENSG00000204574
Uniprot IDs		A0A024R1A3 P22314	A0A1U9X609 Q2L6I2 Q8NE71
PDB IDs		4P22 6DC6 7PYV	5ZXD
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein Modification Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Ubiquitin-dependent Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Nucleoplasm ISG15 Transferase Activity HULC Complex DNA Damage Response ISG15-protein Conjugation Regulation Of Post-translational Protein Modification Free Ubiquitin Chain Polymerization Nucleus DNA Repair Positive Regulation Of Post-translational Protein Modification Protein K29-linked Ubiquitination Cellular Response To Stress Cell Cycle Phase Transition Ubiquitin Binding Regulation Of Protein Modification Process Protein K27-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination TORC1 Signaling DNA Metabolic Process	Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Assembly Of Large Subunit Precursor Of Preribosome Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Lipoprotein Particle Memory Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Histone Deacetylase Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Activating Enzyme Activity Cell Maturation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Axon Midline Choice Point Recognition
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