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PPP2R5D and DELEC1
Number of citations of the paper that reports this interaction (PubMedID
23555304
)
45
Data Source:
BioGRID
(two hybrid)
PPP2R5D
DELEC1
Description
protein phosphatase 2 regulatory subunit B'delta
deleted in esophageal cancer 1
Image
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
Biological Process
Signal Transduction
Nervous System Development
Meiotic Sister Chromatid Cohesion
Negative Regulation Of Cell Population Proliferation
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Estimated glomerular filtration rate (
31015462
)
Interacting Genes
18 interacting genes:
BUB1B
CHEK2
CLOCK
CRY1
CRY2
CSNK1E
CSNK2B
DELEC1
DYDC1
FSD2
HAND1
HAND2
PPFIA1
PPP2R1B
PPP4C
RORC
SGO1
USHBP1
29 interacting genes:
BHLHE41
BMAL1
CIPC
CLOCK
CRY1
CRY2
CSNK1E
CSNK2A1
CSNK2A2
CSNK2B
EZH2
FBXL15
GSK3B
NFIL3
NONO
NPAS2
NR1D2
PER1
PER2
PPP1CA
PPP1CB
PPP1CC
PPP2CA
PPP2R1A
PPP2R1B
PPP2R5D
PPP2R5E
RORB
RORC
Entrez ID
5528
50514
HPRD ID
09039
16068
Ensembl ID
ENSG00000112640
ENSG00000173077
Uniprot IDs
Q14738
PDB IDs
8U1X
8U89
Enriched GO Terms of Interacting Partners
?
Circadian Regulation Of Gene Expression
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Regulation Of Circadian Rhythm
Circadian Rhythm
Blue Light Signaling Pathway
DNA (6-4) Photolyase Activity
Deoxyribodipyrimidine Photo-lyase Activity
Blue Light Photoreceptor Activity
Photoperiodism
Meiotic Sister Chromatid Cohesion, Centromeric
Negative Regulation Of Glucocorticoid Secretion
Rhythmic Process
Cardiac Right Ventricle Formation
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Sister Chromatid Cohesion
Response To Blue Light
Determination Of Heart Left/right Asymmetry
E-box Binding
Cellular Response To Radiation
Cardiac Ventricle Formation
Photoreceptor Activity
Cartilage Morphogenesis
Meiotic Sister Chromatid Cohesion
Cardiac Chamber Formation
Negative Regulation Of Circadian Rhythm
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
DNA Damage Response
Kinase Binding
Positive Regulation Of Circadian Rhythm
Epithelial Tube Morphogenesis
Entrainment Of Circadian Clock By Photoperiod
Regulation Of DNA Damage Checkpoint
Apoptotic Process Involved In Morphogenesis
Entrainment Of Circadian Clock
Nucleus
Signal Transduction In Response To DNA Damage
Lipid Storage
Chromatin
Apoptotic Process Involved In Development
Protein Serine/threonine Kinase Activity
Negative Regulation Of Lipid Transport
FAD Binding
Protein Dimerization Activity
Regulation Of Cell Cycle Phase Transition
Response To Radiation
Negative Regulation Of Intracellular Signal Transduction
Nuclear Receptor Binding
Photoreactive Repair
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Embryonic Heart Tube Formation
Rhythmic Process
Regulation Of Circadian Rhythm
Circadian Rhythm
Circadian Regulation Of Gene Expression
Photoperiodism
Entrainment Of Circadian Clock By Photoperiod
Entrainment Of Circadian Clock
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Protein Phosphatase Type 2A Complex
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Circadian Rhythm
Protein Kinase CK2 Complex
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Chromatin
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
CLOCK-BMAL Transcription Complex
E-box Binding
Glycogen Metabolic Process
Response To Light Stimulus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Primary Metabolic Process
Polysaccharide Metabolic Process
PTW/PP1 Phosphatase Complex
Energy Reserve Metabolic Process
Regulation Of Metabolic Process
Regulation Of Type B Pancreatic Cell Development
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Signal Transduction
Protein Serine/threonine Phosphatase Activity
Regulation Of Signal Transduction
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Phosphatase Regulator Activity
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