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PPP2R5D and CLOCK
Number of citations of the paper that reports this interaction (PubMedID
23555304
)
45
Data Source:
BioGRID
(two hybrid)
PPP2R5D
CLOCK
Description
protein phosphatase 2 regulatory subunit B'delta
clock circadian regulator
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Cytoplasm
Cytosol
Chromatoid Body
CLOCK-BMAL Transcription Complex
Molecular Function
Protein Binding
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Histone Acetyltransferase Activity
Protein Binding
Transferase Activity
Acyltransferase Activity
Chromatin DNA Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Protein-lysine-acetyltransferase Activity
E-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Signal Transduction
Nervous System Development
Meiotic Sister Chromatid Cohesion
DNA Damage Checkpoint Signaling
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Protein Acetylation
DNA Damage Response
Signal Transduction
Spermatogenesis
Circadian Rhythm
Photoperiodism
Regulation Of Gene Expression
Circadian Regulation Of Gene Expression
Regulation Of Hair Cycle
Regulation Of Circadian Rhythm
Positive Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Positive Regulation Of Inflammatory Response
Regulation Of Insulin Secretion
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To Redox State
Cellular Response To Ionizing Radiation
Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
BMAL1:CLOCK,NPAS2 activates circadian expression
BMAL1:CLOCK,NPAS2 activates circadian expression
PPARA activates gene expression
HATs acetylate histones
Heme signaling
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Estimated glomerular filtration rate (
31015462
)
A body shape index (
34021172
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Coronary artery disease (
33020668
)
Cortical surface area (MOSTest) (
32665545
)
Height (
25282103
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Neutrophil percentage of white cells (
32888494
)
Personality dimensions (
18957941
)
Subcortical volume (MOSTest) (
32665545
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
18 interacting genes:
BUB1B
CHEK2
CLOCK
CRY1
CRY2
CSNK1E
CSNK2B
DELEC1
DYDC1
FSD2
HAND1
HAND2
PPFIA1
PPP2R1B
PPP4C
RORC
SGO1
USHBP1
26 interacting genes:
ARNT
BHLHE41
BMAL1
BMAL2
CRY1
CRY2
CSNK1E
CSNK2B
DBP
DELEC1
EP300
KAT2B
PER2
PER3
PPP1CA
PPP1CB
PPP1CC
PPP2R1B
PPP2R5D
PPP2R5E
RARA
RHOA
RORB
RORC
RXRA
SIRT1
Entrez ID
5528
9575
HPRD ID
09039
03508
Ensembl ID
ENSG00000112640
ENSG00000134852
Uniprot IDs
Q14738
O15516
Q3ZCT4
Q53EU0
PDB IDs
8U1X
8U89
4H10
6QPJ
Enriched GO Terms of Interacting Partners
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Circadian Regulation Of Gene Expression
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Regulation Of Circadian Rhythm
Circadian Rhythm
Blue Light Signaling Pathway
DNA (6-4) Photolyase Activity
Deoxyribodipyrimidine Photo-lyase Activity
Blue Light Photoreceptor Activity
Photoperiodism
Meiotic Sister Chromatid Cohesion, Centromeric
Negative Regulation Of Glucocorticoid Secretion
Rhythmic Process
Cardiac Right Ventricle Formation
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Sister Chromatid Cohesion
Response To Blue Light
Determination Of Heart Left/right Asymmetry
E-box Binding
Cellular Response To Radiation
Cardiac Ventricle Formation
Photoreceptor Activity
Cartilage Morphogenesis
Meiotic Sister Chromatid Cohesion
Cardiac Chamber Formation
Negative Regulation Of Circadian Rhythm
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
DNA Damage Response
Kinase Binding
Positive Regulation Of Circadian Rhythm
Epithelial Tube Morphogenesis
Entrainment Of Circadian Clock By Photoperiod
Regulation Of DNA Damage Checkpoint
Apoptotic Process Involved In Morphogenesis
Entrainment Of Circadian Clock
Nucleus
Signal Transduction In Response To DNA Damage
Lipid Storage
Chromatin
Apoptotic Process Involved In Development
Protein Serine/threonine Kinase Activity
Negative Regulation Of Lipid Transport
FAD Binding
Protein Dimerization Activity
Regulation Of Cell Cycle Phase Transition
Response To Radiation
Negative Regulation Of Intracellular Signal Transduction
Nuclear Receptor Binding
Photoreactive Repair
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Embryonic Heart Tube Formation
Circadian Regulation Of Gene Expression
Rhythmic Process
Circadian Rhythm
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock
Entrainment Of Circadian Clock By Photoperiod
Photoperiodism
Regulation Of Transcription By RNA Polymerase II
Response To Light Stimulus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Intracellular Receptor Signaling Pathway
Chromatin
Nucleus
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Regulation Of Glucose Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Radiation
Nuclear Receptor Activity
Gluconeogenesis
Hexose Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Carbohydrate Metabolic Process
PTW/PP1 Phosphatase Complex
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Aryl Hydrocarbon Receptor Complex
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Metabolic Process
Regulation Of Small Molecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nuclear Receptor Binding
Negative Regulation Of Circadian Rhythm
Carbohydrate Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of RNA Metabolic Process
Peptidyl-lysine Acetylation
Negative Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
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Tagcloud (Intersection)
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