PPP2R5D and PPP4C

Number of citations of the paper that reports this interaction (PMID 18715871)
21

Data Source:
HPRD (in vivo)

		PPP2R5D	PPP4C
Gene Name		protein phosphatase 2, regulatory subunit B, delta	protein phosphatase 4, catalytic subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Protein Phosphatase 4 Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity	NF-kappaB-inducing Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Energy Reserve Metabolic Process Nervous System Development Pathogenesis Dephosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Stress-activated MAPK Cascade	Regulation Of Double-strand Break Repair Via Homologous Recombination Dephosphorylation NIK/NF-kappaB Signaling
Pathways		Signaling by GPCR Integration of energy metabolism misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade ERK/MAPK targets truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids Toll Like Receptor 7/8 (TLR7/8) Cascade APC truncation mutants have impaired AXIN binding Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane DARPP-32 events XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CHEK2 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C SGOL1 USHBP1	20 interactors: CCDC6 DHX38 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R4 REL RELA SMEK2 TIPRL TK1 TMSB4X TP53 TRAF6 TRIM28
Entrez ID		5528	5531
HPRD ID		09039	03615
Ensembl ID		ENSG00000112640	ENSG00000149923
Uniprot IDs		Q14738	P60510
PDB IDs
Enriched GO Terms of Interacting Partners?		Cardiac Right Ventricle Formation Cardiac Ventricle Formation Cardiac Chamber Formation Cartilage Morphogenesis Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Morphogenesis Regulation Of Transcription Regulatory Region DNA Binding Apoptotic Process Involved In Development Developmental Programmed Cell Death Negative Regulation Of DNA Binding Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Cardiac Ventricle Morphogenesis Embryonic Heart Tube Development Regulation Of DNA Binding Embryonic Heart Tube Formation Signal Transduction Involved In Intra-S DNA Damage Checkpoint Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Negative Regulation Of Binding Odontogenesis Of Dentin-containing Tooth Cardiac Ventricle Development Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cardiac Left Ventricle Formation Cell Proliferation Involved In Outflow Tract Morphogenesis Visceral Serous Pericardium Development Odontogenesis Cardiac Chamber Development Apoptotic Process Involved In Heart Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Cartilage Development Mesenchyme Development Centriole-centriole Cohesion Norepinephrine Biosynthetic Process Heart Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Coronary Artery Morphogenesis Noradrenergic Neuron Differentiation Apoptotic Process Connective Tissue Development Programmed Cell Death Regulation Of Binding Positive Regulation Of Transcription Regulatory Region DNA Binding Cell Death Death Negative Regulation Of Stress Fiber Assembly	Regulation Of Interleukin-12 Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor 4 Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process NIK/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Transcription, DNA-templated Activation Of Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interleukin-12 Production Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Innate Immune Response Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Death Regulation Of Catalytic Activity Response To Interleukin-1 Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin Signaling Pathway Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Innate Immune Response Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Cytokine Biosynthetic Process Innate Immune Response Immune System Process Membrane Protein Proteolysis Transcription From RNA Polymerase II Promoter Immune Response
Tagcloud ?		altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage	6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapk12 mapped microarray nab2 persistently perturbed plcg1 radiation runx1 scarcity sema4d stathmin1 surgically undertook
Tagcloud (Difference) ?		altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage	6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapk12 mapped microarray nab2 persistently perturbed plcg1 radiation runx1 scarcity sema4d stathmin1 surgically undertook
Tagcloud (Intersection) ?