PPP2R5D and CRY1

Number of citations of the paper that reports this interaction (PubMedID 23555304)
45

Data Source:
BioGRID (two hybrid)

		PPP2R5D	CRY1
Description		protein phosphatase 2 regulatory subunit B'delta	cryptochrome circadian regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Nucleotide Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Histone Deacetylase Binding E-box Binding FAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Signal Transduction Nervous System Development Meiotic Sister Chromatid Cohesion	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Gluconeogenesis Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Signal Transduction In Response To DNA Damage Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of DNA Damage Checkpoint Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Estimated glomerular filtration rate ( 31015462)	Morning person ( 30696823) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		18 interacting genes: BUB1B CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 DYDC1 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C RORC SGO1 USHBP1	25 interacting genes: ARIH1 BHLHE41 BMAL1 CBLB CLOCK CSNK1E DELEC1 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 USP2 USP7
Entrez ID		5528	1407
HPRD ID		09039	09050
Ensembl ID		ENSG00000112640	ENSG00000008405
Uniprot IDs		Q14738	A2I2P0 Q16526
PDB IDs		8U1X 8U89
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Circadian Rhythm Circadian Rhythm Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Photoperiodism Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Glucocorticoid Secretion Rhythmic Process Cardiac Right Ventricle Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Sister Chromatid Cohesion Response To Blue Light Determination Of Heart Left/right Asymmetry E-box Binding Cellular Response To Radiation Cardiac Ventricle Formation Photoreceptor Activity Cartilage Morphogenesis Meiotic Sister Chromatid Cohesion Cardiac Chamber Formation Negative Regulation Of Circadian Rhythm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway DNA Damage Response Kinase Binding Positive Regulation Of Circadian Rhythm Epithelial Tube Morphogenesis Entrainment Of Circadian Clock By Photoperiod Regulation Of DNA Damage Checkpoint Apoptotic Process Involved In Morphogenesis Entrainment Of Circadian Clock Nucleus Signal Transduction In Response To DNA Damage Lipid Storage Chromatin Apoptotic Process Involved In Development Protein Serine/threonine Kinase Activity Negative Regulation Of Lipid Transport FAD Binding Protein Dimerization Activity Regulation Of Cell Cycle Phase Transition Response To Radiation Negative Regulation Of Intracellular Signal Transduction Nuclear Receptor Binding Photoreactive Repair RNA Polymerase II-specific DNA-binding Transcription Factor Binding Embryonic Heart Tube Formation	Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism CLOCK-BMAL Transcription Complex Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Redox State E-box Binding Protein Phosphatase Type 2A Complex Negative Regulation Of RNA Metabolic Process Circadian Behavior Nucleoplasm Rhythmic Behavior Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Hair Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphatase Regulator Activity Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Response To Light Stimulus Meiotic Sister Chromatid Cohesion Regulation Of RNA Metabolic Process Protein Dimerization Activity Negative Regulation Of Macromolecule Metabolic Process Chromatoid Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Membrane Raft Regulation Of Nucleobase-containing Compound Metabolic Process Protein Phosphatase Activator Activity Positive Regulation Of Circadian Rhythm Protein Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Response To Radiation Regulation Of Transcription By RNA Polymerase II Regulation Of Skeletal Muscle Cell Differentiation Transcription Cis-regulatory Region Binding
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