PPP2R5D and SGOL1

Number of citations of the paper that reports this interaction (PMID 16541025)
118

Data Source:
HPRD (in vivo, two hybrid)

		PPP2R5D	SGOL1
Gene Name		protein phosphatase 2, regulatory subunit B, delta	shugoshin-like 1 (S. pombe)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Spindle Pole Nucleoplasm Cytoplasm Centrosome Cytosol Mitotic Cohesin Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity	Protein Binding Kinase Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Energy Reserve Metabolic Process Nervous System Development Pathogenesis Dephosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Stress-activated MAPK Cascade	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division
Pathways		Signaling by GPCR Integration of energy metabolism misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade ERK/MAPK targets truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids Toll Like Receptor 7/8 (TLR7/8) Cascade APC truncation mutants have impaired AXIN binding Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane DARPP-32 events XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Nuclear Events (kinase and transcription factor activation)	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		9 interactors: CHEK2 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C SGOL1 USHBP1	21 interactors: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RPL10A RPL28 RPL7 RPL7A RPLP1 SET UBC XRCC5 XRCC6
Entrez ID		5528	151648
HPRD ID		09039	12377
Ensembl ID		ENSG00000112640	ENSG00000129810
Uniprot IDs		Q14738	B5BUA4 Q5FBB7
PDB IDs			3FGA 3Q6S 4A0I
Enriched GO Terms of Interacting Partners?		Cardiac Right Ventricle Formation Cardiac Ventricle Formation Cardiac Chamber Formation Cartilage Morphogenesis Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Morphogenesis Regulation Of Transcription Regulatory Region DNA Binding Apoptotic Process Involved In Development Developmental Programmed Cell Death Negative Regulation Of DNA Binding Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Cardiac Ventricle Morphogenesis Embryonic Heart Tube Development Regulation Of DNA Binding Embryonic Heart Tube Formation Signal Transduction Involved In Intra-S DNA Damage Checkpoint Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Negative Regulation Of Binding Odontogenesis Of Dentin-containing Tooth Cardiac Ventricle Development Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cardiac Left Ventricle Formation Cell Proliferation Involved In Outflow Tract Morphogenesis Visceral Serous Pericardium Development Odontogenesis Cardiac Chamber Development Apoptotic Process Involved In Heart Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Cartilage Development Mesenchyme Development Centriole-centriole Cohesion Norepinephrine Biosynthetic Process Heart Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Coronary Artery Morphogenesis Noradrenergic Neuron Differentiation Apoptotic Process Connective Tissue Development Programmed Cell Death Regulation Of Binding Positive Regulation Of Transcription Regulatory Region DNA Binding Cell Death Death Negative Regulation Of Stress Fiber Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Cellular Macromolecule Catabolic Process Viral Process Viral Life Cycle Viral Transcription Protein Complex Disassembly SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Catabolic Process Aromatic Compound Catabolic Process Protein Localization To Endoplasmic Reticulum Translational Termination MRNA Metabolic Process Protein Targeting To Membrane Membrane Organization Translational Elongation Cellular Protein Complex Disassembly Positive Regulation Of Type I Interferon Production Double-strand Break Repair Via Nonhomologous End Joining Cellular Hyperosmotic Salinity Response Establishment Of Protein Localization To Membrane Translational Initiation Mitotic Cell Cycle Regulation Of Type I Interferon Production Cellular Response To X-ray Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Establishment Of Protein Localization To Organelle Apoptotic Process Fibroblast Growth Factor Receptor Signaling Pathway Protein Localization To Membrane Programmed Cell Death Mitotic Cell Cycle Process Cell Death Death Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cytoplasmic Transport Cellular Response To Stress Establishment Of Integrated Proviral Latency Cellular Response To Fibroblast Growth Factor Stimulus Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Response To Fibroblast Growth Factor Cellular Hyperosmotic Response Hyperosmotic Salinity Response Protein Targeting
Tagcloud ?		altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage	amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 subtype ttk tumorigenic upregulated
Tagcloud (Difference) ?		altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage	amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 subtype ttk tumorigenic upregulated
Tagcloud (Intersection) ?