FANCL and CCDC36

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FANCL	CCDC36
Gene Name		Fanconi anemia, complementation group L	coiled-coil domain containing 36
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Regulation Of Cell Proliferation
Pathways		Fanconi Anemia pathway
Drugs
Diseases
GWAS		Body mass index ( 20935630) Obesity ( 23563607)
Protein-Protein Interactions		24 interactors: ACVR1 BMPR1B C17orf70 CCDC36 CHCHD3 DOCK8 EIF4ENIF1 FANCB FANCD2 FANCI GGN GRN HES1 IKZF3 KIFC3 LZTS2 PCNA RBM45 RIMBP3 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W	33 interactors: ABI2 AQP1 C1orf109 CARD9 CDC23 COX5B DGCR6 DYNLL1 DYNLL2 FAM124A FANCL FKBP6 GYS1 HEXIM2 IQUB KANK2 KLC3 LMO2 LONRF1 MRFAP1L1 MVP MYO15B NEK6 NGB POLR1C PRKAB2 RUNX1T1 SDCBP STK25 TRIM42 TTC19 USP2 USP20
Entrez ID		55120	339834
HPRD ID		06997	14172
Ensembl ID		ENSG00000115392	ENSG00000173421
Uniprot IDs		B5MC31 B5MCZ6 Q9NW38	B4DZP6 Q8IYA8
PDB IDs		3ZQS
Enriched GO Terms of Interacting Partners?		Pharyngeal System Development DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Single Organism Reproductive Process Pathway-restricted SMAD Protein Phosphorylation Response To Stress Reproductive Process Mesenchymal Cell Development Protein K11-linked Ubiquitination Epithelial Cell Fate Commitment Gamete Generation Mesenchymal Cell Differentiation Movement Of Cell Or Subcellular Component Activin Receptor Signaling Pathway Cellular Response To Stress Urogenital System Development Cellular Response To Stimulus Sexual Reproduction Multicellular Organismal Reproductive Process Positive Regulation Of Bone Mineralization Protein Monoubiquitination Positive Regulation Of Biomineral Tissue Development Multicellular Organism Reproduction Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Mesenchyme Development Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-threonine Phosphorylation In Utero Embryonic Development Nucleobase-containing Compound Metabolic Process Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Positive Regulation Of Deoxyribonuclease Activity Pharyngeal Arch Artery Morphogenesis Memory T Cell Proliferation Lateral Inhibition Endocardial Cushion Cell Fate Commitment Cell Cycle Heart Morphogenesis Heart Development Smooth Muscle Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cardiac Septum Morphogenesis Thymus Development Stem Cell Development Heterocycle Metabolic Process	Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Organelle Organization Organelle Organization Regulation Of Cell Cycle Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Cycle Regulation Of Proteolysis Regulation Of Protein Catabolic Process Ammonium Transmembrane Transport Positive Regulation Of Organelle Organization Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Synaptic Target Recognition Regulation Of Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitochondrion Organization Cellular Response To Hydrogen Peroxide Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Vitamin D Receptor Signaling Pathway Carbon Dioxide Transmembrane Transport Corticotropin Secretion Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Cell Cycle Phase Transition Positive Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ammonium Transport Proteasomal Protein Catabolic Process
Tagcloud ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified vrk2
Tagcloud (Difference) ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified vrk2
Tagcloud (Intersection) ?