FANCL and FAAP100

Number of citations of the paper that reports this interaction (PubMedID 17396147)
42

Data Source:
HPRD (two hybrid, in vivo)

		FANCL	FAAP100
Description		FA complementation group L	FA core complex associated protein 100
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Nuclear Body Fanconi Anaemia Nuclear Complex	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding
	Biological Process	DNA Repair Protein Monoubiquitination DNA Damage Response Gamete Generation Protein Ubiquitination Interstrand Cross-link Repair Regulation Of Cell Population Proliferation	DNA Repair DNA Damage Response Interstrand Cross-link Repair
Pathways		Fanconi Anemia Pathway PKR-mediated signaling	Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases		Fanconi anemia
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 20935630 31453325) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Epilepsy ( 30531953 25087078) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Generalized epilepsy ( 30531953) HDL cholesterol levels ( 32203549) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 29483656 25056061) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		48 interacting genes: ACTMAP ACVR1 ANTKMT BMPR1B CADPS CERCAM CHCHD3 CTBP1 CTDSP1 CYB5R2 DDAH2 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GATA1 GGN GRN HDHD3 HES1 HOXD4 ID2 IHO1 IKZF3 KIFC3 KRTAP11-1 KRTAP13-2 KRTAP19-6 LZTS2 METTL15 MORN3 PCNA RBM45 RIMBP3 RNF11 SCNM1 SNF8 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W UFSP1 YPEL3 ZNF581	10 interacting genes: APP ATRIP CFTR FANCB FANCF FANCL HOXA1 LINC00839 MDFI PTGES3L-AARSD1
Entrez ID		55120	80233
HPRD ID		06997	07982
Ensembl ID		ENSG00000115392	ENSG00000185504
Uniprot IDs		A0A8Q3SIK5 A0A8Q3SIR9 C9J512 H7C1M0 Q9NW38	A4ZI32 Q0VG06
PDB IDs		3ZQS 4CCG 7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Interstrand Cross-link Repair Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Fanconi Anaemia Nuclear Complex DNA Repair DNA Metabolic Process DNA Polymerase Binding Negative Regulation Of Neuron Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Protein Binding Cell Fate Commitment Ventricular Septum Morphogenesis BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition DNA Damage Response Nucleus SMAD Binding Activin Binding Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Chromatin DNA Repair Complex	Fanconi Anaemia Nuclear Complex Interstrand Cross-link Repair Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Visual Behavior Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To CAMP Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Cellular Response To Stress Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport DNA Metabolic Process DNA Repair DNA Damage Response Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior ATR-ATRIP Complex Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Catalase Activity Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Carbon Monoxide Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Enamel Mineralization Superoxide Dismutase Activity
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