FANCL and C17orf70

Number of citations of the paper that reports this interaction (PMID 17396147)
52

Data Source:
HPRD (in vivo, two hybrid)

		FANCL	C17orf70
Gene Name		Fanconi anemia, complementation group L	chromosome 17 open reading frame 70
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex	Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex Intermediate Filament Cytoskeleton
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding
	Biological Process	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Regulation Of Cell Proliferation	DNA Repair
Pathways		Fanconi Anemia pathway	Fanconi Anemia pathway
Drugs
Diseases
GWAS		Body mass index ( 20935630) Obesity ( 23563607)
Protein-Protein Interactions		24 interactors: ACVR1 BMPR1B C17orf70 CCDC36 CHCHD3 DOCK8 EIF4ENIF1 FANCB FANCD2 FANCI GGN GRN HES1 IKZF3 KIFC3 LZTS2 PCNA RBM45 RIMBP3 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W	4 interactors: APP FANCB FANCL MDFI
Entrez ID		55120	80233
HPRD ID		06997	07982
Ensembl ID		ENSG00000115392	ENSG00000185504
Uniprot IDs		B5MC31 B5MCZ6 Q9NW38	A4ZI32 Q0VG06
PDB IDs		3ZQS
Enriched GO Terms of Interacting Partners?		Pharyngeal System Development DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Single Organism Reproductive Process Pathway-restricted SMAD Protein Phosphorylation Response To Stress Reproductive Process Mesenchymal Cell Development Protein K11-linked Ubiquitination Epithelial Cell Fate Commitment Gamete Generation Mesenchymal Cell Differentiation Movement Of Cell Or Subcellular Component Activin Receptor Signaling Pathway Cellular Response To Stress Urogenital System Development Cellular Response To Stimulus Sexual Reproduction Multicellular Organismal Reproductive Process Positive Regulation Of Bone Mineralization Protein Monoubiquitination Positive Regulation Of Biomineral Tissue Development Multicellular Organism Reproduction Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Mesenchyme Development Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-threonine Phosphorylation In Utero Embryonic Development Nucleobase-containing Compound Metabolic Process Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Positive Regulation Of Deoxyribonuclease Activity Pharyngeal Arch Artery Morphogenesis Memory T Cell Proliferation Lateral Inhibition Endocardial Cushion Cell Fate Commitment Cell Cycle Heart Morphogenesis Heart Development Smooth Muscle Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cardiac Septum Morphogenesis Thymus Development Stem Cell Development Heterocycle Metabolic Process	Synaptic Growth At Neuromuscular Junction Response To Stress Collateral Sprouting In Absence Of Injury Reproductive Process Regulation Of Binding Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Axon Choice Point Recognition Neuron Remodeling
Tagcloud ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified vrk2
Tagcloud (Difference) ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified vrk2
Tagcloud (Intersection) ?