IHO1 and EAF2

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		IHO1	EAF2
Description		interactor of HORMAD1 1	ELL associated factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Chromosome	Nucleus Nucleoplasm Transcription Elongation Factor Complex Nuclear Speck Super Elongation Complex
	Molecular Function	Protein Binding	Transcription Elongation Factor Activity Protein Binding
	Biological Process	DNA Recombination Homologous Chromosome Pairing At Meiosis Spermatogenesis Cell Differentiation Meiotic DNA Double-strand Break Formation Oogenesis Meiotic Cell Cycle Regulation Of Homologous Chromosome Segregation	Transcription Elongation By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Growth Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways			Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Interacting Genes		78 interacting genes: ABI2 ABI3 ADAMTS12 AIRIM AQP1 ARHGEF9 ATP6V0D1 BCL6 BOLA2 BOLA2B CARD9 CCDC120 CCDC57 CDC23 CFAP206 COX5B DGCR6 DVL2 DYNLL1 DYNLL2 EAF2 EFHC1 EXOC8 FAM124A FAM124B FANCG FANCL FASLG FHL3 FKBP6 GEM GLRX3 GLYCTK GOLGA2 GRAP2 GYS1 HEXIM2 HINFP IQUB KANK2 KIF9 KIFC3 KLC3 KLHL11 LMO2 LNX1 LONRF1 MAGEB4 MAGOHB MAPK9 MID2 MRFAP1L1 MVP MYO15B NEK6 NFKBID NGB PICK1 POLR1C PRKAB2 PRR34 RABGEF1 RAD51D RHOBTB3 RUNX1T1 SDCBP SMARCB1 STK25 TNS2 TRIM14 TRIM42 TTC19 USP2 USP20 ZGPAT ZKSCAN3 ZNF417 ZNF688	20 interacting genes: BEND7 BIRC2 ELL GOLGA2 HIF1A IHO1 LNX2 NECAB2 PNMA1 PSME3 RBPMS SSX2IP STAC3 TCEA1 TCEA2 TFIP11 TFPT TLE5 TP53 TRIM23
Entrez ID		339834	55840
HPRD ID		14172	09634
Ensembl ID		ENSG00000173421	ENSG00000145088
Uniprot IDs		B4DZP6 Q8IYA8	B4DWJ3 Q96CJ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoplasm Identical Protein Binding [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex Negative Regulation Of Mast Cell Cytokine Production Cytoskeleton Microtubule-based Process Regulation Of Cellular Senescence Microtubule Centrosome Iron-sulfur Cluster Assembly Intracellular Iron Ion Homeostasis	Identical Protein Binding Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation P53 Binding Regulation Of Thymocyte Apoptotic Process Cis-regulatory Region Sequence-specific DNA Binding MDM2/MDM4 Family Protein Binding Necroptotic Process Lactate Metabolic Process Neural Precursor Cell Proliferation Programmed Necrotic Cell Death Transcription Elongation Factor Complex
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