FANCL and DDAH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FANCL	DDAH2
Description		FA complementation group L	DDAH family member 2, ADMA-independent
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Nuclear Body Fanconi Anaemia Nuclear Complex	Cytoplasm Mitochondrion Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Dimethylargininase Activity Hydrolase Activity
	Biological Process	DNA Repair Protein Monoubiquitination DNA Damage Response Gamete Generation Protein Ubiquitination Interstrand Cross-link Repair Regulation Of Cell Population Proliferation	Citrulline Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process
Pathways		Fanconi Anemia Pathway PKR-mediated signaling
Drugs			Citrulline
Diseases		Fanconi anemia
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 20935630 31453325) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Epilepsy ( 30531953 25087078) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Generalized epilepsy ( 30531953) HDL cholesterol levels ( 32203549) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 29483656 25056061) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Ulcerative colitis ( 28067908)
Interacting Genes		48 interacting genes: ACTMAP ACVR1 ANTKMT BMPR1B CADPS CERCAM CHCHD3 CTBP1 CTDSP1 CYB5R2 DDAH2 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GATA1 GGN GRN HDHD3 HES1 HOXD4 ID2 IHO1 IKZF3 KIFC3 KRTAP11-1 KRTAP13-2 KRTAP19-6 LZTS2 METTL15 MORN3 PCNA RBM45 RIMBP3 RNF11 SCNM1 SNF8 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W UFSP1 YPEL3 ZNF581	28 interacting genes: ACTN3 ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 FANCL GADD45G IGFN1 MAP3K20 MKNK1 NOXA1 PIN1 PRKAB2 RAP1B RCC1 RPS6KA1 RPS6KA5 SCGN SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14
Entrez ID		55120	23564
HPRD ID		06997	09204
Ensembl ID		ENSG00000115392	ENSG00000213722
Uniprot IDs		A0A8Q3SIK5 A0A8Q3SIR9 C9J512 H7C1M0 Q9NW38	O95865 V9HW53
PDB IDs		3ZQS 4CCG 7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Interstrand Cross-link Repair Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Fanconi Anaemia Nuclear Complex DNA Repair DNA Metabolic Process DNA Polymerase Binding Negative Regulation Of Neuron Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Protein Binding Cell Fate Commitment Ventricular Septum Morphogenesis BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition DNA Damage Response Nucleus SMAD Binding Activin Binding Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Chromatin DNA Repair Complex	Cytoplasm Nucleus Regulation Of Mitotic Cell Cycle Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Intracellular Signal Transduction Cytosol Regulation Of Cell Cycle Process Protein Kinase Activity JNK Cascade Response To Phorbol 13-acetate 12-myristate Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Positive Regulation Of Programmed Cell Death Epithelial Cell Proliferation Cellular Response To UV-B Protein Phosphorylation Identical Protein Binding Intracellular Signaling Cassette Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Phosphorylation Magnesium Ion Binding Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Phase Transition Regulation Of Translation In Response To Stress Positive Regulation Of JNK Cascade Response To UV-B Regulation Of Cell Cycle Phase Transition Cellular Response To Gamma Radiation Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Regulation Of Multicellular Organismal Process Protein Binding Z Disc Phosphate-containing Compound Metabolic Process Signal Transduction Nucleotide Binding ATP Binding Cyclin Binding Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Nuclear Division Cis-trans Isomerase Activity Positive Regulation Of Apoptotic Process Histone H2AS1 Kinase Activity Positive Regulation Of Mitotic DNA Damage Checkpoint
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?