IHO1 and STK25

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		IHO1	STK25
Description		interactor of HORMAD1 1	serine/threonine kinase 25
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Chromosome	Cytoplasm Golgi Apparatus Extracellular Exosome FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	DNA Recombination Homologous Chromosome Pairing At Meiosis Spermatogenesis Cell Differentiation Meiotic DNA Double-strand Break Formation Oogenesis Meiotic Cell Cycle Regulation Of Homologous Chromosome Segregation	Protein Phosphorylation Response To Oxidative Stress Establishment Or Maintenance Of Cell Polarity Signal Transduction Axonogenesis Positive Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Protein Autophosphorylation Positive Regulation Of Axonogenesis Golgi Localization Establishment Of Golgi Localization Golgi Reassembly
Pathways
Drugs
Diseases
GWAS			Medication use (thyroid preparations) ( 31015401) Prostate cancer ( 23535732) Vitiligo ( 27723757)
Interacting Genes		78 interacting genes: ABI2 ABI3 ADAMTS12 AIRIM AQP1 ARHGEF9 ATP6V0D1 BCL6 BOLA2 BOLA2B CARD9 CCDC120 CCDC57 CDC23 CFAP206 COX5B DGCR6 DVL2 DYNLL1 DYNLL2 EAF2 EFHC1 EXOC8 FAM124A FAM124B FANCG FANCL FASLG FHL3 FKBP6 GEM GLRX3 GLYCTK GOLGA2 GRAP2 GYS1 HEXIM2 HINFP IQUB KANK2 KIF9 KIFC3 KLC3 KLHL11 LMO2 LNX1 LONRF1 MAGEB4 MAGOHB MAPK9 MID2 MRFAP1L1 MVP MYO15B NEK6 NFKBID NGB PICK1 POLR1C PRKAB2 PRR34 RABGEF1 RAD51D RHOBTB3 RUNX1T1 SDCBP SMARCB1 STK25 TNS2 TRIM14 TRIM42 TTC19 USP2 USP20 ZGPAT ZKSCAN3 ZNF417 ZNF688	17 interacting genes: APP CCNDBP1 CEP70 GOLGA2 GOLGA6L9 IHO1 IKBKG LRRK2 MFHAS1 MTDH NEDD4 OGT PDCD10 TRIM27 UBE2D3 YWHAZ ZDHHC17
Entrez ID		339834	10494
HPRD ID		14172	03770
Ensembl ID		ENSG00000173421	ENSG00000115694
Uniprot IDs		B4DZP6 Q8IYA8	A0A024R4B2 A0A0S2Z4Y2 B3KRS6 B4DMA5 B4DVS7 B4E185 O00506 Q96BA2
PDB IDs			2XIK 3W8H 4NZW 7Z4V
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoplasm Identical Protein Binding [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex Negative Regulation Of Mast Cell Cytokine Production Cytoskeleton Microtubule-based Process Regulation Of Cellular Senescence Microtubule Centrosome Iron-sulfur Cluster Assembly Intracellular Iron Ion Homeostasis	Positive Regulation Of Intracellular Signal Transduction Regulation Of Synapse Organization Positive Regulation Of Protein Metabolic Process Cellular Response To Catecholamine Stimulus Positive Regulation Of Signal Transduction Response To Catecholamine Regulation Of Intracellular Signal Transduction Regulation Of Autophagy Positive Regulation Of Proteolysis Positive Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Golgi Organization Golgi Reassembly Protein Modification Process Positive Regulation Of Catabolic Process Phosphoserine Residue Binding Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization Cellular Response To Dopamine Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Response To Dopamine Positive Regulation Of Autophagy Establishment Of Golgi Localization Innate Immune Response Regulation Of Proteolysis Cellular Response To Manganese Ion Regulation Of MAPK Cascade Negative Regulation Of RNA Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Progesterone Receptor Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Defense Response To Symbiont Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Localization In Cell
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