FANCL and FANCI

Number of citations of the paper that reports this interaction (PMID 21775430)
8

Data Source:
BioGRID (unspecified method, enzymatic study, enzymatic study)

		FANCL	FANCI
Gene Name		Fanconi anemia, complementation group L	Fanconi anemia, complementation group I
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding DNA Polymerase Binding
	Biological Process	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Regulation Of Cell Proliferation	DNA Repair Cell Cycle Positive Regulation Of Protein Ubiquitination
Pathways		Fanconi Anemia pathway	Fanconi Anemia pathway Regulation of the Fanconi anemia pathway
Drugs
Diseases
GWAS		Body mass index ( 20935630) Obesity ( 23563607)
Protein-Protein Interactions		24 interactors: ACVR1 BMPR1B C17orf70 CCDC36 CHCHD3 DOCK8 EIF4ENIF1 FANCB FANCD2 FANCI GGN GRN HES1 IKZF3 KIFC3 LZTS2 PCNA RBM45 RIMBP3 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W	4 interactors: APP FANCD2 FANCL WDR48
Entrez ID		55120	55215
HPRD ID		06997	13339
Ensembl ID		ENSG00000115392	ENSG00000140525
Uniprot IDs		B5MC31 B5MCZ6 Q9NW38	B3KNW8 Q9NVI1
PDB IDs		3ZQS
Enriched GO Terms of Interacting Partners?		Pharyngeal System Development DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Single Organism Reproductive Process Pathway-restricted SMAD Protein Phosphorylation Response To Stress Reproductive Process Mesenchymal Cell Development Protein K11-linked Ubiquitination Epithelial Cell Fate Commitment Gamete Generation Mesenchymal Cell Differentiation Movement Of Cell Or Subcellular Component Activin Receptor Signaling Pathway Cellular Response To Stress Urogenital System Development Cellular Response To Stimulus Sexual Reproduction Multicellular Organismal Reproductive Process Positive Regulation Of Bone Mineralization Protein Monoubiquitination Positive Regulation Of Biomineral Tissue Development Multicellular Organism Reproduction Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Mesenchyme Development Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-threonine Phosphorylation In Utero Embryonic Development Nucleobase-containing Compound Metabolic Process Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Positive Regulation Of Deoxyribonuclease Activity Pharyngeal Arch Artery Morphogenesis Memory T Cell Proliferation Lateral Inhibition Endocardial Cushion Cell Fate Commitment Cell Cycle Heart Morphogenesis Heart Development Smooth Muscle Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cardiac Septum Morphogenesis Thymus Development Stem Cell Development Heterocycle Metabolic Process	Sexual Reproduction Reproduction Reproductive Process DNA Repair Gamete Generation Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cellular Response To DNA Damage Stimulus Regulation Of Protein Monoubiquitination Synaptic Growth At Neuromuscular Junction DNA Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Single Organism Reproductive Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Axon Choice Point Recognition Nucleobase-containing Compound Metabolic Process Neuron Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Growth Seminiferous Tubule Development Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Monoubiquitination Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Response To Gamma Radiation Cellular Protein Modification Process
Tagcloud ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified vrk2	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a ube2v2
Tagcloud (Difference) ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified vrk2	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a ube2v2
Tagcloud (Intersection) ?