FANCL and GGN

Number of citations of the paper that reports this interaction (PMID 12574169)
10

Data Source:
HPRD (in vivo, two hybrid)

		FANCL	GGN
Gene Name		Fanconi anemia, complementation group L	gametogenetin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex	Nucleolus Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Protein Dimerization Activity
	Biological Process	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Regulation Of Cell Proliferation	Multicellular Organismal Development Gamete Generation Spermatogenesis Protein Localization Cell Differentiation
Pathways		Fanconi Anemia pathway
Drugs
Diseases
GWAS		Body mass index ( 20935630) Obesity ( 23563607)
Protein-Protein Interactions		24 interactors: ACVR1 BMPR1B C17orf70 CCDC36 CHCHD3 DOCK8 EIF4ENIF1 FANCB FANCD2 FANCI GGN GRN HES1 IKZF3 KIFC3 LZTS2 PCNA RBM45 RIMBP3 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W	7 interactors: BRCA1 ECT2 FANCL GGNBP1 GGNBP2 KRT40 OAZ3
Entrez ID		55120	199720
HPRD ID		06997	17036
Ensembl ID		ENSG00000115392	ENSG00000179168
Uniprot IDs		B5MC31 B5MCZ6 Q9NW38	Q86UU5
PDB IDs		3ZQS
Enriched GO Terms of Interacting Partners?		Pharyngeal System Development DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Single Organism Reproductive Process Pathway-restricted SMAD Protein Phosphorylation Response To Stress Reproductive Process Mesenchymal Cell Development Protein K11-linked Ubiquitination Epithelial Cell Fate Commitment Gamete Generation Mesenchymal Cell Differentiation Movement Of Cell Or Subcellular Component Activin Receptor Signaling Pathway Cellular Response To Stress Urogenital System Development Cellular Response To Stimulus Sexual Reproduction Multicellular Organismal Reproductive Process Positive Regulation Of Bone Mineralization Protein Monoubiquitination Positive Regulation Of Biomineral Tissue Development Multicellular Organism Reproduction Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Mesenchyme Development Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-threonine Phosphorylation In Utero Embryonic Development Nucleobase-containing Compound Metabolic Process Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Positive Regulation Of Deoxyribonuclease Activity Pharyngeal Arch Artery Morphogenesis Memory T Cell Proliferation Lateral Inhibition Endocardial Cushion Cell Fate Commitment Cell Cycle Heart Morphogenesis Heart Development Smooth Muscle Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cardiac Septum Morphogenesis Thymus Development Stem Cell Development Heterocycle Metabolic Process	Gamete Generation Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Reproduction Single Organism Reproductive Process Reproductive Process Spermatogenesis Male Gamete Generation Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Putrescine Transport Positive Regulation Of Histone H3-K9 Acetylation Response To Ionizing Radiation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Microtubule-based Process Negative Regulation Of Polyamine Transmembrane Transport Cellular Response To Indole-3-methanol Positive Regulation Of Cell Cycle Process Negative Regulation Of Centriole Replication Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Apoptotic Signaling Pathway Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Activation Of Rac GTPase Activity Negative Regulation Of Histone Methylation Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Cellular Response To Stress Polyamine Biosynthetic Process Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Cdc42 GTPase Activity Negative Regulation Of Protein Acetylation
Tagcloud ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified vrk2	bcg bovis confocal domain except gfp gga immunoblot immunofluorescence localization localizes maintain missing mtb mycobacteria mycobacterial mycobacterium pathogenic pe pgrs pgrs30 polar poles repeats repetitive smegmatis tagged unique virulence
Tagcloud (Difference) ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified vrk2	bcg bovis confocal domain except gfp gga immunoblot immunofluorescence localization localizes maintain missing mtb mycobacteria mycobacterial mycobacterium pathogenic pe pgrs pgrs30 polar poles repeats repetitive smegmatis tagged unique virulence
Tagcloud (Intersection) ?