FANCL and CERCAM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FANCL	CERCAM
Description		FA complementation group L	cerebral endothelial cell adhesion molecule
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Nuclear Body Fanconi Anaemia Nuclear Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding Procollagen Galactosyltransferase Activity
	Biological Process	DNA Repair Protein Monoubiquitination DNA Damage Response Gamete Generation Protein Ubiquitination Interstrand Cross-link Repair Regulation Of Cell Population Proliferation	Cell Adhesion Leukocyte Cell-cell Adhesion
Pathways		Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases		Fanconi anemia
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 20935630 31453325) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Epilepsy ( 30531953 25087078) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Generalized epilepsy ( 30531953) HDL cholesterol levels ( 32203549) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 29483656 25056061) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172)	Body mass index ( 26426971) Systemic lupus erythematosus ( 26606652)
Interacting Genes		48 interacting genes: ACTMAP ACVR1 ANTKMT BMPR1B CADPS CERCAM CHCHD3 CTBP1 CTDSP1 CYB5R2 DDAH2 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GATA1 GGN GRN HDHD3 HES1 HOXD4 ID2 IHO1 IKZF3 KIFC3 KRTAP11-1 KRTAP13-2 KRTAP19-6 LZTS2 METTL15 MORN3 PCNA RBM45 RIMBP3 RNF11 SCNM1 SNF8 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W UFSP1 YPEL3 ZNF581	38 interacting genes: ABHD5 ATG9A CDC23 CREB5 CYSRT1 DSCR9 FANCL FKBP7 FNDC11 GEMIN4 GLRX3 GOPC HOXA1 KLHL38 KRTAP15-1 KRTAP26-1 KRTAP3-3 KRTAP6-2 KRTAP8-1 KRTAP9-3 LASP1 LCOR MAGED1 MKRN3 OTX1 P4HA3 POGZ POU4F2 RBM11 RHOXF2 RUNX1 SFT2D1 SOHLH1 TENT5B UBL5 VENTX VGLL3 ZDHHC15
Entrez ID		55120	51148
HPRD ID		06997	16705
Ensembl ID		ENSG00000115392	ENSG00000167123
Uniprot IDs		A0A8Q3SIK5 A0A8Q3SIR9 C9J512 H7C1M0 Q9NW38	Q5T4B2
PDB IDs		3ZQS 4CCG 7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Interstrand Cross-link Repair Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Fanconi Anaemia Nuclear Complex DNA Repair DNA Metabolic Process DNA Polymerase Binding Negative Regulation Of Neuron Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Protein Binding Cell Fate Commitment Ventricular Septum Morphogenesis BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition DNA Damage Response Nucleus SMAD Binding Activin Binding Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Chromatin DNA Repair Complex	Intermediate Filament Chromatin
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