INTS11 and OTX1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		INTS11	OTX1
Name		integrator complex subunit 11	orthodenticle homeobox 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Integrator Complex Blood Microparticle INTAC Complex	Chromatin Nucleus
	Molecular Function	RNA Endonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II SnRNA 3'-end Processing RNA Polymerase II Transcription Initiation Surveillance	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Metencephalon Development Forebrain Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	None
GWAS		No GWAS studies recorded	Fruit consumption ( 32066663 ) Neurociticism ( 29500382 ) Regular attendance at a religious group ( 29970889 ) Risk-taking tendency (4-domain principal component model) ( 30643258 )
Interacting Genes		39 interacting genes: ANXA7 C1orf94 CCDC120 CREB5 CSNK2B DSE FAM222B GPS2 HSF4 INTS9 KRTAP15-1 KRTAP26-1 LASP1 LENG8 MDFI NSMF OTX1 OXER1 PKN1 PLK1 PLSCR1 PLSCR4 PROP1 PRR35 SNRPC SPAG8 SPIC TBX6 TCF7L2 TFG TK1 TLX3 TRIP13 USP2 VAC14 VENTX YPEL3 ZC3H10 ZIC1	148 interacting genes: ADAM12 ADAMTSL4 ALPP ANKRD10 ARHGEF17 ARID5A ATG9B C10orf55 CCN4 CERCAM CFAP68 CH25H CHIC2 CHRD CHRDL2 COL8A1 COMP CTAG2 CYSRT1 DPY30 EFEMP2 ETFDH FAM168B FAM72B FBLN2 FBLN5 FHL5 GEMIN8P4 GPRASP3 GPRIN2 GRN HIVEP1 HOXA1 INTS11 KCNK16 KLHL26 KPRP KRT31 KRT35 KRT37 KRT81 KRT85 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LGALS13 M1AP MDFI MGAT5B MIIP MTNR1B NBPF19 NDUFAF6 NECTIN3 NHLRC4 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLEKHG4 PLSCR2 POU2AF1 PRICKLE4 PRR13 PRR22 RBPMS RGS17 RGS19 RGS20 RNF144B RTN4R SLC15A2 SMARCC1 SPMIP9 SPRY1 SPRY2 SPRY4 SPRYD7 TLE4 TNS2 TRIM42 TRIP6 TSPAN4 UBAP2 USP54 VWC2 VWC2L WWOX YPEL3 ZBTB42 ZNF330 ZNF34
Entrez ID		54973	5013
HPRD ID		13377	08964
Ensembl ID		ENSG00000127054	ENSG00000115507
Uniprot IDs		A0A087WYI0 Q5TA45	P32242
PDB IDs		5V8W 7BFP 7BFQ 7CUN 7PKS 7YCX 8R22 8R23 8R2D 8RBX 8RBZ 8RC4 8UIB 8YJB	Not available
GO Terms Enriched among Interactors		Nucleus Regulation Of Transcription By RNA Polymerase II Chromatin Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription CD4 Receptor Binding Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Separation	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Protein Binding Structural Molecule Activity Cytosol Structural Constituent Of Skin Epidermis Negative Regulation Of Cellular Response To Growth Factor Stimulus