INTS11 and INTS9

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, cross-linking study)
HPRD (two hybrid, in vivo)

		INTS11	INTS9
Description		integrator complex subunit 11	integrator complex subunit 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Integrator Complex Blood Microparticle INTAC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Integrator Complex INTAC Complex
	Molecular Function	RNA Endonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II SnRNA 3'-end Processing RNA Polymerase II Transcription Initiation Surveillance	SnRNA Processing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription Elongation By RNA Polymerase II SnRNA 3'-end Processing Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus RNA Polymerase II Transcription Initiation Surveillance
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS			High density lipoprotein cholesterol levels ( 30498476)
Interacting Genes		39 interacting genes: ANXA7 C1orf94 CCDC120 CREB5 CSNK2B DSE FAM222B GPS2 HSF4 INTS9 KRTAP15-1 KRTAP26-1 LASP1 LENG8 MDFI NSMF OTX1 OXER1 PKN1 PLK1 PLSCR1 PLSCR4 PROP1 PRR35 SNRPC SPAG8 SPIC TBX6 TCF7L2 TFG TK1 TLX3 TRIP13 USP2 VAC14 VENTX YPEL3 ZC3H10 ZIC1	2 interacting genes: INTS11 TXNIP
Entrez ID		54973	55756
HPRD ID		13377	07706
Ensembl ID		ENSG00000127054	ENSG00000104299
Uniprot IDs		A0A087WYI0 Q5TA45	Q9NV88
PDB IDs		5V8W 7BFP 7BFQ 7CUN 7PKS 7YCX 8R22 8R23 8R2D 8RBX 8RBZ 8RC4 8UIB 8YJB	5V8W 7BFP 7BFQ 7CUN 7PKS 7YCX 8R22 8R23 8R2D 8RBX 8RBZ 8RC4 8UIB 8YJB
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Chromatin Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription CD4 Receptor Binding Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Separation	Response To Progesterone Cellular Response To Lipoprotein Particle Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Cell Division Cellular Response To Tumor Cell SnRNA Processing Nuclear RNA Surveillance RNA Surveillance RNA Endonuclease Activity SnRNA 3'-end Processing Integrator Complex INTAC Complex RNA Polymerase II Transcription Initiation Surveillance Transcription Elongation By RNA Polymerase II SnRNA Metabolic Process DNA-templated Transcription Elongation Enzyme Inhibitor Activity
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