COMMD8 and TEC

		COMMD8	TEC
Description		COMM domain containing 8	tec protein tyrosine kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	Protein Binding NF-kappaB Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Signal Transduction	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Neddylation	Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Risk-taking tendency (4-domain principal component model) ( 30643258)	Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)
Interacting Genes		5 interacting genes: AKR1C1 COMMD1 COXFA4L2 TMX2 ZNF474	37 interacting genes: ARHGEF12 BMX BTK DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		54951	7006
HPRD ID		13086	02786
Ensembl ID		ENSG00000169019	ENSG00000135605
Uniprot IDs		Q9NX08	P42680
PDB IDs		8F2R 8F2U 8P0W	2LUL
Enriched GO Terms of Interacting Partners?		17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Indanol Dehydrogenase Activity Sterol Homeostasis 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity Cellular Response To Jasmonic Acid Stimulus Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Cholesterol Homeostasis Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Ketosteroid Monooxygenase Activity Lipid Homeostasis Regulation Of Plasma Lipoprotein Particle Levels 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Regulation Of Cholesterol Import Daunorubicin Metabolic Process Carboxylic Acid Binding Androsterone Dehydrogenase [NAD(P)+] Activity Doxorubicin Metabolic Process Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Testosterone Dehydrogenase (NADP+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Bile Acid Binding Disulfide Oxidoreductase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Negative Regulation Of Sodium Ion Transmembrane Transport Intestinal Cholesterol Absorption Aldose Reductase (NADPH) Activity Plasma Membrane To Endosome Transport Alcohol Dehydrogenase (NADP+) Activity Negative Regulation Of Protein Localization To Cell Surface Intestinal Lipid Absorption Negative Regulation Of Cellular Response To Hypoxia Progesterone Metabolic Process Negative Regulation Of Sodium Ion Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Lipid Binding Low-density Lipoprotein Particle Clearance Retinal Metabolic Process Respiratory Chain Complex IV Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling Bile Acid And Bile Salt Transport Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Regulation Of Cellular Response To Hypoxia	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process
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