RHBDL2 and TMBIM6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHBDL2	TMBIM6
Description		rhomboid like 2	transmembrane BAX inhibitor motif containing 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity
	Biological Process	Proteolysis	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Menopause (age at onset) ( 22267201 26414677) Severe autoimmune type 2 diabetes ( 34737425) Sweet beverage consumption ( 31046077) Triglyceride levels ( 32203549)	General cognitive ability ( 29844566)
Interacting Genes		4 interacting genes: EFNB2 EFNB3 SLC35B4 TMBIM6	66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A
Entrez ID		54933	7009
HPRD ID		07151	02851
Ensembl ID		ENSG00000158315	ENSG00000139644
Uniprot IDs		B7Z1Y9 Q9NX52	P55061
PDB IDs
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Ephrin Receptor Signaling Pathway Ephrin Receptor Binding Virus Receptor Activity Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Positive Regulation Of Aorta Morphogenesis Presynaptic Membrane Symbiont Entry Into Host Cell Negative Regulation Of Neuron Projection Development Endoribonuclease Inhibitor Activity Biological Process Involved In Interaction With Host UDP-N-acetylglucosamine Transmembrane Transporter Activity UDP-N-acetylglucosamine Transmembrane Transport Negative Regulation Of Cell Projection Organization Regulation Of Aorta Morphogenesis Negative Regulation Of Calcium Ion Transport Into Cytosol Neuron Projection Guidance Axon Guidance Positive Regulation Of Artery Morphogenesis Trans-synaptic Signaling By Trans-synaptic Complex Axon Choice Point Recognition Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of T Cell Activation Venous Blood Vessel Morphogenesis Nephric Duct Morphogenesis Regulation Of Artery Morphogenesis Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cardiac Muscle Cell Differentiation IRE1-mediated Unfolded Protein Response Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Lymph Vessel Development Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Presynapse Assembly Trans-synaptic Signaling, Modulating Synaptic Transmission Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Immunoglobulin Production Positive Regulation Of Cardiocyte Differentiation Transmembrane-ephrin Receptor Activity Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Activator Activity	Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport
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