RHBDL2 and EFNB3

Number of citations of the paper that reports this interaction (PubMedID 15047175)
0

Data Source:
HPRD (in vitro)

		RHBDL2	EFNB3
Description		rhomboid like 2	ephrin B3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane Presynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Virus Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Proteolysis	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Axon Choice Point Recognition Cell Differentiation T Cell Costimulation Symbiont Entry Into Host Cell Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Menopause (age at onset) ( 22267201 26414677) Severe autoimmune type 2 diabetes ( 34737425) Sweet beverage consumption ( 31046077) Triglyceride levels ( 32203549)	Alcohol consumption ( 31358974)
Interacting Genes		4 interacting genes: EFNB2 EFNB3 SLC35B4 TMBIM6	8 interacting genes: AATF ELOC EPHA4 EPHB3 P2RX7 RELN RHBDL2 YWHAZ
Entrez ID		54933	1949
HPRD ID		07151	03804
Ensembl ID		ENSG00000158315	ENSG00000108947
Uniprot IDs		B7Z1Y9 Q9NX52	Q15768
PDB IDs			4BKF
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Ephrin Receptor Signaling Pathway Ephrin Receptor Binding Virus Receptor Activity Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Positive Regulation Of Aorta Morphogenesis Presynaptic Membrane Symbiont Entry Into Host Cell Negative Regulation Of Neuron Projection Development Endoribonuclease Inhibitor Activity Biological Process Involved In Interaction With Host UDP-N-acetylglucosamine Transmembrane Transporter Activity UDP-N-acetylglucosamine Transmembrane Transport Negative Regulation Of Cell Projection Organization Regulation Of Aorta Morphogenesis Negative Regulation Of Calcium Ion Transport Into Cytosol Neuron Projection Guidance Axon Guidance Positive Regulation Of Artery Morphogenesis Trans-synaptic Signaling By Trans-synaptic Complex Axon Choice Point Recognition Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of T Cell Activation Venous Blood Vessel Morphogenesis Nephric Duct Morphogenesis Regulation Of Artery Morphogenesis Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cardiac Muscle Cell Differentiation IRE1-mediated Unfolded Protein Response Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Lymph Vessel Development Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Presynapse Assembly Trans-synaptic Signaling, Modulating Synaptic Transmission Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Immunoglobulin Production Positive Regulation Of Cardiocyte Differentiation Transmembrane-ephrin Receptor Activity Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Activator Activity	Neuron Recognition Regulation Of Synapse Organization Cell Recognition Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Axonal Fasciculation Neuron Projection Fasciculation Central Nervous System Projection Neuron Axonogenesis Regulation Of Synapse Maturation Positive Regulation Of Dendrite Morphogenesis Neuron Projection Guidance Axon Guidance Central Nervous System Neuron Axonogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Long-term Synaptic Potentiation Regulation Of Dendritic Spine Morphogenesis Regulation Of Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Nervous System Development Ephrin Receptor Signaling Pathway Regulation Of Dendrite Morphogenesis DH Domain Binding Lysosome Organization Positive Regulation Of Lateral Motor Column Neuron Migration Reelin Complex Spinal Cord Patterning Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Projection Organization Neuromuscular Junction Fasciculation Of Motor Neuron Axon Positive Regulation Of Bleb Assembly Synaptic Target Recognition Regulation Of Dendrite Development Regulation Of Neuron Projection Development Regulation Of Nervous System Development Protein Metabolic Process Macromolecule Catabolic Process Neuron Projection Development Dendrite Fasciculation Of Sensory Neuron Axon Cell Projection Organization Phospholipid Transfer To Membrane Positive Regulation Of Gamma-aminobutyric Acid Secretion Lateral Motor Column Neuron Migration Lipoprotein Particle Receptor Binding Positive Regulation Of Cellular Component Organization Protein Tyrosine Kinase Activity Phagolysosome Assembly NAD Transport
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