RHBDL2 and EFNB2

Number of citations of the paper that reports this interaction (PubMedID 15047175)
0

Data Source:
HPRD (in vitro)

		RHBDL2	EFNB2
Description		rhomboid like 2	ephrin B2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Adherens Junction Focal Adhesion Membrane Dendrite Presynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Virus Receptor Activity Signaling Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Ephrin Receptor Binding Receptor Ligand Activity
	Biological Process	Proteolysis	Angiogenesis Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation T Cell Costimulation Adherens Junction Organization Keratinocyte Proliferation Symbiont Entry Into Host Cell Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Venous Blood Vessel Morphogenesis Regulation Of Chemotaxis Cellular Response To Lipopolysaccharide Nephric Duct Morphogenesis Presynapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Aorta Morphogenesis Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Menopause (age at onset) ( 22267201 26414677) Severe autoimmune type 2 diabetes ( 34737425) Sweet beverage consumption ( 31046077) Triglyceride levels ( 32203549)	BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		4 interacting genes: EFNB2 EFNB3 SLC35B4 TMBIM6	23 interacting genes: ANKRD46 DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RELN RGS3 RHBDL2 SDCBP SRC
Entrez ID		54933	1948
HPRD ID		07151	02754
Ensembl ID		ENSG00000158315	ENSG00000125266
Uniprot IDs		B7Z1Y9 Q9NX52	P52799
PDB IDs			2HLE 2I85 2VSK 2VSM 2WO2 3GXU 4UF7 6P7Y 6PDL
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Ephrin Receptor Signaling Pathway Ephrin Receptor Binding Virus Receptor Activity Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Positive Regulation Of Aorta Morphogenesis Presynaptic Membrane Symbiont Entry Into Host Cell Negative Regulation Of Neuron Projection Development Endoribonuclease Inhibitor Activity Biological Process Involved In Interaction With Host UDP-N-acetylglucosamine Transmembrane Transporter Activity UDP-N-acetylglucosamine Transmembrane Transport Negative Regulation Of Cell Projection Organization Regulation Of Aorta Morphogenesis Negative Regulation Of Calcium Ion Transport Into Cytosol Neuron Projection Guidance Axon Guidance Positive Regulation Of Artery Morphogenesis Trans-synaptic Signaling By Trans-synaptic Complex Axon Choice Point Recognition Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of T Cell Activation Venous Blood Vessel Morphogenesis Nephric Duct Morphogenesis Regulation Of Artery Morphogenesis Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cardiac Muscle Cell Differentiation IRE1-mediated Unfolded Protein Response Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Lymph Vessel Development Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Presynapse Assembly Trans-synaptic Signaling, Modulating Synaptic Transmission Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Immunoglobulin Production Positive Regulation Of Cardiocyte Differentiation Transmembrane-ephrin Receptor Activity Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Activator Activity	Ephrin Receptor Signaling Pathway Ephrin Receptor Activity Dendrite Transmembrane-ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Cell Surface Receptor Signaling Pathway Plasma Membrane Neuron Projection Organization Positive Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Neuron Projection Cell Recognition Protein Tyrosine Kinase Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Postsynaptic Density Regulation Of Synaptic Transmission, Glutamatergic Cell Projection Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Organization Cell Migration Regulation Of Synapse Organization Regulation Of Cell Projection Organization Signal Transduction Synapse Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Cell Communication Postsynapse Organization Glutamatergic Synapse Regulation Of Signaling Neuron Projection Guidance Cell Motility Axon Guidance Postsynaptic Membrane Regulation Of Signal Transduction Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Regulation Of Cell Morphogenesis Positive Regulation Of Signaling Cell Adhesion Dendritic Spine Development Regulation Of Postsynapse Organization Regulation Of Nervous System Development G Protein-coupled Glutamate Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Response To Amyloid-beta
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