LIME1 and PLCG2

Number of citations of the paper that reports this interaction (PMID 16249387)
4

Data Source:
HPRD (in vivo)

		LIME1	PLCG2
Gene Name		Lck interacting transmembrane adaptor 1	phospholipase C, gamma 2 (phosphatidylinositol-specific)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane	Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function		Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Protein Binding
	Biological Process	T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Follicular B Cell Differentiation Phosphatidylinositol Biosynthetic Process Blood Coagulation Phospholipid Catabolic Process Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Platelet Activation B Cell Differentiation Activation Of Store-operated Calcium Channel Activity Response To Lipopolysaccharide Inositol Trisphosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Programmed Cell Death Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol
Pathways			Signaling by the B Cell Receptor (BCR) DAP12 interactions FCERI mediated MAPK activation Inositol phosphate metabolism DAP12 signaling Toll-Like Receptors Cascades Synthesis of IP3 and IP4 in the cytosol Toll Like Receptor 4 (TLR4) Cascade Role of phospholipids in phagocytosis GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Platelet activation, signaling and aggregation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Prostate cancer ( 23535732)
Protein-Protein Interactions		4 interactors: GRB2 LCK LYN PLCG2	34 interactors: BLK BLNK BTK CBLB CD19 DAPP1 EGFR EPOR ERBB2 FCER1G FLT1 FYN GAB1 GAB2 HCK IRS1 ITK JAK1 JAK2 KDR KHDRBS1 LAT LAT2 LCK LCP2 LIME1 LYN NPM1 PRKD1 SH3BP2 SHC1 SYK TEC ZNF512B
Entrez ID		54923	5336
HPRD ID		07904	02570
Ensembl ID		ENSG00000203896	ENSG00000197943
Uniprot IDs		Q9H400	P16885
PDB IDs			2K2J 2W2W 2W2X
Enriched GO Terms of Interacting Partners?		Platelet Activation Fc-epsilon Receptor Signaling Pathway B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Blood Coagulation Hemostasis T Cell Costimulation Immune Response-regulating Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Immune Response Cell Activation Antigen Receptor-mediated Signaling Pathway Response To Wounding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Ion Homeostasis Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Phagocytosis Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Immune Response Regulation Of Immune System Process Cellular Response To Peptide Leukocyte Differentiation Defense Response Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Regulation Of Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Calcium Ion Transport Into Cytosol Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cytosolic Calcium Ion Transport Response To Peptide Hormone Regulation Of Cell Activation Cellular Response To Organonitrogen Compound Leukocyte Activation	Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Immune Response Protein Autophosphorylation Immune System Process Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Defense Response Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Cell Communication B Cell Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Peptidyl-amino Acid Modification Cell Activation Positive Regulation Of Signal Transduction Response To Stimulus Response To Stress Leukocyte Activation Protein Phosphorylation Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Activation Cell Migration Locomotion Phosphorylation Cell Motility Mast Cell Activation Phosphatidylinositol-mediated Signaling Wound Healing Leukocyte Migration Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway
Tagcloud ?			16x10 associations chrne comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl
Tagcloud (Difference) ?			16x10 associations chrne comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl
Tagcloud (Intersection) ?