LIME1 and STX7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIME1	STX7
Description		Lck interacting transmembrane adaptor 1	syntaxin 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane B Cell Receptor Complex	Immunological Synapse Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Plasma Membrane Synaptic Vesicle Endomembrane System Membrane Endocytic Vesicle SNARE Complex Early Endosome Membrane Vesicle Azurophil Granule Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Tertiary Granule Secretory Vesicle
	Molecular Function	Protein Binding Protein Kinase Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding
	Biological Process	Adaptive Immune Response Immune System Process Regulation Of Transcription By RNA Polymerase II Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction	Positive Regulation Of T Cell Mediated Cytotoxicity Intracellular Protein Transport Vesicle Fusion Vesicle-mediated Transport Vesicle Docking Organelle Localization Organelle Assembly Positive Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bell's palsy ( 33602968) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 23128233 28067908) Lipoprotein (a) levels ( 33730874) Meat-related diet ( 32066663) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908)	A body shape index ( 34021172) Cutaneous leishmaniasis ( 32830257) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		46 interacting genes: AGR3 AIG1 AQP1 ARFGAP3 BNIP2 C14orf180 CALN1 CIAO2A CLN6 EMD FRMD8 GAD2 GOSR2 GRB2 LCK LHFPL5 LPAR3 LYN MAN2B2 MEST MIEF2 NDRG4 NINJ1 PBX3 PKMYT1 PLCG2 PNPO PTPN9 RTP2 SEC22C SLC41A2 SNAP47 SNX1 STX6 STX7 TBRG4 TMBIM6 TMEM143 TMEM243 TMEM74 TMEM86B TMEM97 TRAF3IP3 UNC93B1 UPK2 ZFPL1	52 interacting genes: ANKS6 AQP6 ARL13B CERS4 CISD2 CREB3 CREB3L1 CYBRD1 EBP ELOVL5 ENTPD2 FAM174A FAM210B FKBP7 GJC3 HSD17B11 HSD17B13 JAGN1 LIME1 LMNA MAPK6 MFF MGST3 MRM1 MTUS1 NAPA REEP1 RETREG3 RIC3 SAR1A SLC10A1 SLC10A6 SLC18A1 SLC35D4 SNAP29 STX1A STX2 STX6 STX8 TM4SF19 TMEM205 TMEM267 TMEM80 TMPRSS2 TMX2 VAMP7 VAMP8 VPS11 VPS16 VPS18 VTI1B ZFYVE27
Entrez ID		54923	8417
HPRD ID		07904	04449
Ensembl ID		ENSG00000203896	ENSG00000079950
Uniprot IDs		A0A087WT39 Q9H400	O15400
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex B Cell Receptor Signaling Pathway Organelle Fusion Lysosome Ephrin Receptor Binding Regulation Of Cellular Localization Vesicle Organization Plasma Membrane Organelle Membrane Fusion Vesicle Fusion Protein Binding Phosphotyrosine Residue Binding T Cell Costimulation Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Phosphorylation-dependent Protein Binding Syntaxin Binding Fc Receptor Signaling Pathway Golgi Apparatus Vesicle Docking Spindle Pole Centrosome Antigen Receptor-mediated Signaling Pathway Endomembrane System SNARE Binding Immune Response-regulating Signaling Pathway Membrane Fusion Vesicle-mediated Transport Activation Of Immune Response	Organelle Membrane Fusion Vesicle Fusion Membrane Fusion SNAP Receptor Activity Organelle Fusion SNARE Complex Organelle Localization By Membrane Tethering Membrane Membrane Docking Vesicle Organization Syntaxin Binding Vesicle Docking Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Binding Chloride Channel Inhibitor Activity Membrane Organization Establishment Of Protein Localization Protein Transport Autophagosome Maturation Intracellular Protein Transport CORVET Complex Organelle Localization Vesicle-mediated Transport Endomembrane System Lysosomal Membrane Intracellular Protein Localization Autophagy Protein Binding Protein-containing Complex Disassembly Vesicle Docking Involved In Exocytosis Establishment Of Localization In Cell Late Endosome Membrane HOPS Complex Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Organelle Organization Endosome To Lysosome Transport Steroid Dehydrogenase Activity Cellular Localization Endoplasmic Reticulum Tubular Network Organization Exocytosis Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Cytoplasmic Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Positive Regulation Of Histamine Secretion By Mast Cell Vesicle Tethering Complex Recycling Endosome Presynaptic Active Zone Membrane
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