LIME1 and SNAP47

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIME1	SNAP47
Description		Lck interacting transmembrane adaptor 1	synaptosome associated protein 47
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane B Cell Receptor Complex	Cytoplasm Plasma Membrane Endomembrane System Membrane BLOC-1 Complex SNARE Complex Synapse Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Protein Binding Protein Kinase Binding	SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Adaptive Immune Response Immune System Process Regulation Of Transcription By RNA Polymerase II Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction	Exocytosis Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bell's palsy ( 33602968) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 23128233 28067908) Lipoprotein (a) levels ( 33730874) Meat-related diet ( 32066663) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908)	Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Night sleep phenotypes ( 27126917) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		46 interacting genes: AGR3 AIG1 AQP1 ARFGAP3 BNIP2 C14orf180 CALN1 CIAO2A CLN6 EMD FRMD8 GAD2 GOSR2 GRB2 LCK LHFPL5 LPAR3 LYN MAN2B2 MEST MIEF2 NDRG4 NINJ1 PBX3 PKMYT1 PLCG2 PNPO PTPN9 RTP2 SEC22C SLC41A2 SNAP47 SNX1 STX6 STX7 TBRG4 TMBIM6 TMEM143 TMEM243 TMEM74 TMEM86B TMEM97 TRAF3IP3 UNC93B1 UPK2 ZFPL1	23 interacting genes: APOC2 APOC4 AQP2 CEP57L1 F11R FAM9B FATE1 GOLGA2 KASH5 KLC3 LIME1 LRRC4C MAGEA6 MGST3 MID2 PVR RNF170 SAR1A SPAG5 STX1A STX1B STX4 TRIM59
Entrez ID		54923	116841
HPRD ID		07904	17148
Ensembl ID		ENSG00000203896	ENSG00000143740
Uniprot IDs		A0A087WT39 Q9H400	A0A087X0B7 Q5SQN1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex B Cell Receptor Signaling Pathway Organelle Fusion Lysosome Ephrin Receptor Binding Regulation Of Cellular Localization Vesicle Organization Plasma Membrane Organelle Membrane Fusion Vesicle Fusion Protein Binding Phosphotyrosine Residue Binding T Cell Costimulation Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Phosphorylation-dependent Protein Binding Syntaxin Binding Fc Receptor Signaling Pathway Golgi Apparatus Vesicle Docking Spindle Pole Centrosome Antigen Receptor-mediated Signaling Pathway Endomembrane System SNARE Binding Immune Response-regulating Signaling Pathway Membrane Fusion Vesicle-mediated Transport Activation Of Immune Response	Microtubule Binding SNAP Receptor Activity SNARE Complex Microtubule Synaptic Vesicle Docking Regulation Of Synaptic Vesicle Priming SNARE Complex Assembly SNARE Binding Vesicle Docking Ciliary Rootlet Organelle Localization By Membrane Tethering Very-low-density Lipoprotein Particle Positive Regulation Of Neurotransmitter Secretion Organelle Localization Schaffer Collateral - CA1 Synapse Membrane Docking Neurotransmitter Transport Vesicle Fusion Organelle Membrane Fusion High-density Lipoprotein Particle Host-mediated Suppression Of Symbiont Invasion Presynaptic Active Zone Membrane Organelle Fusion Vesicle Organization Positive Regulation Of Excitatory Postsynaptic Potential Calcium-ion Regulated Exocytosis Positive Regulation Of Synaptic Transmission Synaptic Vesicle Exocytosis Acylglycerol Homeostasis Triglyceride Homeostasis Spindle Organization Vesicle Docking Involved In Exocytosis Myosin Head/neck Binding Membrane Fusion Sphingomyelin Phosphodiesterase Activator Activity Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling Identical Protein Binding Intracellular Protein Localization Positive Regulation Of Regulated Secretory Pathway Modulation Of Excitatory Postsynaptic Potential Protein Localization To Cytoskeleton Germ Cell Development Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity Susceptibility To T Cell Mediated Cytotoxicity Exocytosis Positive Regulation Of Eosinophil Degranulation
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