LIME1 and PNPO

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIME1	PNPO
Description		Lck interacting transmembrane adaptor 1	pyridoxamine 5'-phosphate oxidase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane B Cell Receptor Complex	Mitochondrion Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding	Pyridoxamine Phosphate Oxidase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors Pyridoxal Phosphate Binding Protein Homodimerization Activity
	Biological Process	Adaptive Immune Response Immune System Process Regulation Of Transcription By RNA Polymerase II Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction	Pyridoxine Biosynthetic Process Pyridoxamine Metabolic Process Pyridoxal Phosphate Metabolic Process Pyridoxal Phosphate Biosynthetic Process
Pathways			Vitamin B6 activation to pyridoxal phosphate
Drugs			Pyridoxal phosphate Flavin mononucleotide Mercaptoethanol
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bell's palsy ( 33602968) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 23128233 28067908) Lipoprotein (a) levels ( 33730874) Meat-related diet ( 32066663) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908)	Body mass index ( 26426971) Generalized epilepsy ( 22949513 30531953)
Interacting Genes		46 interacting genes: AGR3 AIG1 AQP1 ARFGAP3 BNIP2 C14orf180 CALN1 CIAO2A CLN6 EMD FRMD8 GAD2 GOSR2 GRB2 LCK LHFPL5 LPAR3 LYN MAN2B2 MEST MIEF2 NDRG4 NINJ1 PBX3 PKMYT1 PLCG2 PNPO PTPN9 RTP2 SEC22C SLC41A2 SNAP47 SNX1 STX6 STX7 TBRG4 TMBIM6 TMEM143 TMEM243 TMEM74 TMEM86B TMEM97 TRAF3IP3 UNC93B1 UPK2 ZFPL1	4 interacting genes: AGTRAP APP CMTM5 LIME1
Entrez ID		54923	55163
HPRD ID		07904	04476
Ensembl ID		ENSG00000203896	ENSG00000108439
Uniprot IDs		A0A087WT39 Q9H400	Q9NVS9 V9HW45
PDB IDs			1NRG 3HY8 6H00 8QYT 8QYW 8ROS
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex B Cell Receptor Signaling Pathway Organelle Fusion Lysosome Ephrin Receptor Binding Regulation Of Cellular Localization Vesicle Organization Plasma Membrane Organelle Membrane Fusion Vesicle Fusion Protein Binding Phosphotyrosine Residue Binding T Cell Costimulation Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Phosphorylation-dependent Protein Binding Syntaxin Binding Fc Receptor Signaling Pathway Golgi Apparatus Vesicle Docking Spindle Pole Centrosome Antigen Receptor-mediated Signaling Pathway Endomembrane System SNARE Binding Immune Response-regulating Signaling Pathway Membrane Fusion Vesicle-mediated Transport Activation Of Immune Response	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Calcium Ion Transport Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling B Cell Receptor Complex Angiotensin Type II Receptor Activity Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Axon Choice Point Recognition Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Chemotaxis Cellular Response To Manganese Ion Extracellular Space Regulation Of Metal Ion Transport Antifungal Humoral Response Locomotion Nuclear Envelope Lumen
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