LIME1 and FRMD8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIME1	FRMD8
Description		Lck interacting transmembrane adaptor 1	FERM domain containing 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane B Cell Receptor Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Centriolar Satellite
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Regulation Of Transcription By RNA Polymerase II Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction	Positive Regulation Of Tumor Necrosis Factor Production Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bell's palsy ( 33602968) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 23128233 28067908) Lipoprotein (a) levels ( 33730874) Meat-related diet ( 32066663) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908)	Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Serum uric acid levels ( 32271837 32514006) Urate levels ( 31578528)
Interacting Genes		46 interacting genes: AGR3 AIG1 AQP1 ARFGAP3 BNIP2 C14orf180 CALN1 CIAO2A CLN6 EMD FRMD8 GAD2 GOSR2 GRB2 LCK LHFPL5 LPAR3 LYN MAN2B2 MEST MIEF2 NDRG4 NINJ1 PBX3 PKMYT1 PLCG2 PNPO PTPN9 RTP2 SEC22C SLC41A2 SNAP47 SNX1 STX6 STX7 TBRG4 TMBIM6 TMEM143 TMEM243 TMEM74 TMEM86B TMEM97 TRAF3IP3 UNC93B1 UPK2 ZFPL1	9 interacting genes: APP FATE1 GRAMD2B IKBKG KCNH2 LIME1 PLEKHF2 ZNF446 ZNF474
Entrez ID		54923	83786
HPRD ID		07904	13326
Ensembl ID		ENSG00000203896	ENSG00000126391
Uniprot IDs		A0A087WT39 Q9H400	A8K6L3 Q9BZ67
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex B Cell Receptor Signaling Pathway Organelle Fusion Lysosome Ephrin Receptor Binding Regulation Of Cellular Localization Vesicle Organization Plasma Membrane Organelle Membrane Fusion Vesicle Fusion Protein Binding Phosphotyrosine Residue Binding T Cell Costimulation Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Phosphorylation-dependent Protein Binding Syntaxin Binding Fc Receptor Signaling Pathway Golgi Apparatus Vesicle Docking Spindle Pole Centrosome Antigen Receptor-mediated Signaling Pathway Endomembrane System SNARE Binding Immune Response-regulating Signaling Pathway Membrane Fusion Vesicle-mediated Transport Activation Of Immune Response	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Monoatomic Ion Transport Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Cation Homeostasis Regulation Of Metal Ion Transport Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Heart Rate By Hormone Ubiquitin Protein Ligase Binding T Cell Receptor Signaling Pathway Linear Polyubiquitin Binding Monoatomic Ion Homeostasis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling B Cell Receptor Complex Negative Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of Calcium Ion Transmembrane Transport Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Heart Rate By Chemical Signal Inward Rectifier Potassium Channel Complex Antigen Receptor-mediated Signaling Pathway Regulation Of Spontaneous Synaptic Transmission Homeostatic Process
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