LIME1 and LPAR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIME1	LPAR3
Description		Lck interacting transmembrane adaptor 1	lysophosphatidic acid receptor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane B Cell Receptor Complex	Cytoplasm Plasma Membrane Cilium Membrane Axon Synapse
	Molecular Function	Protein Binding Protein Kinase Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding Phospholipid Binding Lipid Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Adaptive Immune Response Immune System Process Regulation Of Transcription By RNA Polymerase II Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Gene Expression Bleb Assembly Positive Regulation Of MAPK Cascade Collateral Sprouting Positive Regulation Of Collateral Sprouting Positive Regulation Of Calcium Ion Transport
Pathways			G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bell's palsy ( 33602968) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 23128233 28067908) Lipoprotein (a) levels ( 33730874) Meat-related diet ( 32066663) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908)	Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Dental caries ( 23064961) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		46 interacting genes: AGR3 AIG1 AQP1 ARFGAP3 BNIP2 C14orf180 CALN1 CIAO2A CLN6 EMD FRMD8 GAD2 GOSR2 GRB2 LCK LHFPL5 LPAR3 LYN MAN2B2 MEST MIEF2 NDRG4 NINJ1 PBX3 PKMYT1 PLCG2 PNPO PTPN9 RTP2 SEC22C SLC41A2 SNAP47 SNX1 STX6 STX7 TBRG4 TMBIM6 TMEM143 TMEM243 TMEM74 TMEM86B TMEM97 TRAF3IP3 UNC93B1 UPK2 ZFPL1	61 interacting genes: APP AQP6 ARL13B ASZ1 BCL2L13 C16orf54 CD53 CD74 CD79A CLDN2 CLDN7 CLDN9 CLEC12B CPLX4 CREB3L1 CYB561 CYBRD1 EDA ELOVL4 ERGIC3 FAM209A FAM210B FFAR2 FNDC9 GJB5 GNAI2 GORAB GPX8 HSD17B13 JAGN1 KCNC1 KCNJ6 LEPROTL1 LHFPL5 LIME1 LMNA MFF MGST3 MRM1 MS4A4A MUC1 NDUFAF2 OPRM1 PGRMC2 RELL2 RETREG3 SCN3B SGMS2 SHISAL1 SLC10A6 SLC16A2 SLC35H1 TFEC THAP4 TMEM14B TMEM237 TMEM31 TMEM41A TMEM52B TMEM70 TMEM79
Entrez ID		54923	23566
HPRD ID		07904	05486
Ensembl ID		ENSG00000203896	ENSG00000171517
Uniprot IDs		A0A087WT39 Q9H400	Q9UBY5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex B Cell Receptor Signaling Pathway Organelle Fusion Lysosome Ephrin Receptor Binding Regulation Of Cellular Localization Vesicle Organization Plasma Membrane Organelle Membrane Fusion Vesicle Fusion Protein Binding Phosphotyrosine Residue Binding T Cell Costimulation Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Phosphorylation-dependent Protein Binding Syntaxin Binding Fc Receptor Signaling Pathway Golgi Apparatus Vesicle Docking Spindle Pole Centrosome Antigen Receptor-mediated Signaling Pathway Endomembrane System SNARE Binding Immune Response-regulating Signaling Pathway Membrane Fusion Vesicle-mediated Transport Activation Of Immune Response	Membrane Protein Binding Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion Ascorbate Homeostasis Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules B Cell Receptor Complex Transmembrane Monodehydroascorbate Reductase Activity Negative Regulation Of Protein Secretion Negative Regulation Of Secretion By Cell
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