MTMR10 and SMAD5

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MTMR10	SMAD5
Description		myotubularin related protein 10	SMAD family member 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function		RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Negative Regulation Of Gene Expression Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway
Pathways		Synthesis of PIPs at the early endosome membrane	Signaling by BMP
Drugs
Diseases
GWAS		Huntington's disease progression ( 28642124) Hypertriglyceridemia ( 23505323)	Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)
Interacting Genes		10 interacting genes: AATK DSCAM ERBB3 HUNK LCOR MEOX2 NRIP1 PTK7 SMAD5 SMAD9	47 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 ROCK1 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8
Entrez ID		54893	4090
HPRD ID		07895	04381
Ensembl ID		ENSG00000166912	ENSG00000113658
Uniprot IDs		Q9NXD2 X5D963	Q68DB7 Q99717
PDB IDs			6FZS 6TCE
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Protein Kinase Activity Cellular Response To Estradiol Stimulus Nuclear Estrogen Receptor Binding Tissue Development Mesenchyme Development Embryonic Pattern Specification Ovarian Follicle Rupture Intracellular Iron Ion Homeostasis Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Wound Healing Negative Regulation Of Fas Signaling Pathway BMP Signaling Pathway Neuregulin Receptor Activity Neuron Apoptotic Process Stem Cell Differentiation Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Response To Estradiol Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Protein Tyrosine Kinase Activity Striated Muscle Tissue Development Osteoblast Differentiation Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway Mullerian Duct Regression Chromatin Somite Specification Cellular Response To Lipid Histone Deacetylase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Muscle Tissue Development Schwann Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway DEAD/H-box RNA Helicase Binding Netrin-activated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process BMP Signaling Pathway SMAD Binding Negative Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process R-SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway DNA-templated Transcription Response To Growth Factor Epithelial Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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