MTMR10 and HUNK

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		MTMR10	HUNK
Description		myotubularin related protein 10	hormonally up-regulated Neu-associated kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cytoplasm
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process		Signal Transduction Intracellular Signal Transduction
Pathways		Synthesis of PIPs at the early endosome membrane
Drugs
Diseases
GWAS		Huntington's disease progression ( 28642124) Hypertriglyceridemia ( 23505323)	Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)
Interacting Genes		10 interacting genes: AATK DSCAM ERBB3 HUNK LCOR MEOX2 NRIP1 PTK7 SMAD5 SMAD9	92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793
Entrez ID		54893	30811
HPRD ID		07895	09410
Ensembl ID		ENSG00000166912	ENSG00000142149
Uniprot IDs		Q9NXD2 X5D963	P57058
PDB IDs
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Protein Kinase Activity Cellular Response To Estradiol Stimulus Nuclear Estrogen Receptor Binding Tissue Development Mesenchyme Development Embryonic Pattern Specification Ovarian Follicle Rupture Intracellular Iron Ion Homeostasis Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Wound Healing Negative Regulation Of Fas Signaling Pathway BMP Signaling Pathway Neuregulin Receptor Activity Neuron Apoptotic Process Stem Cell Differentiation Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Response To Estradiol Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Protein Tyrosine Kinase Activity Striated Muscle Tissue Development Osteoblast Differentiation Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway Mullerian Duct Regression Chromatin Somite Specification Cellular Response To Lipid Histone Deacetylase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Muscle Tissue Development Schwann Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway DEAD/H-box RNA Helicase Binding Netrin-activated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway	Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity
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