MTMR10 and AATK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		MTMR10	AATK
Description		myotubularin related protein 10	apoptosis associated tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cytoplasm Endomembrane System Membrane Perinuclear Region Of Cytoplasm
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process		Brain Development Neuron Apoptotic Process
Pathways		Synthesis of PIPs at the early endosome membrane
Drugs
Diseases
GWAS		Huntington's disease progression ( 28642124) Hypertriglyceridemia ( 23505323)	Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		10 interacting genes: AATK DSCAM ERBB3 HUNK LCOR MEOX2 NRIP1 PTK7 SMAD5 SMAD9	41 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2
Entrez ID		54893	9625
HPRD ID		07895	05591
Ensembl ID		ENSG00000166912	ENSG00000181409
Uniprot IDs		Q9NXD2 X5D963	H7C175 Q6ZMQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Protein Kinase Activity Cellular Response To Estradiol Stimulus Nuclear Estrogen Receptor Binding Tissue Development Mesenchyme Development Embryonic Pattern Specification Ovarian Follicle Rupture Intracellular Iron Ion Homeostasis Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Wound Healing Negative Regulation Of Fas Signaling Pathway BMP Signaling Pathway Neuregulin Receptor Activity Neuron Apoptotic Process Stem Cell Differentiation Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Response To Estradiol Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Protein Tyrosine Kinase Activity Striated Muscle Tissue Development Osteoblast Differentiation Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway Mullerian Duct Regression Chromatin Somite Specification Cellular Response To Lipid Histone Deacetylase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Muscle Tissue Development Schwann Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway DEAD/H-box RNA Helicase Binding Netrin-activated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway	Phosphoprotein Phosphatase Activity Dephosphorylation Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Protein Modification Process Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cytoplasm MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Negative Regulation Of Signaling Regulation Of Signal Transduction Cytosol Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Negative Regulation Of Cell Communication Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Phosphatase Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of MAPK Cascade Phosphatidylinositol Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Peptidyl-threonine Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Phospholipid Dephosphorylation Macromolecule Metabolic Process Intracellular Signaling Cassette Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Intracellular Signal Transduction ERK1 And ERK2 Cascade Manganese Ion Binding Cerebellar Cortex Formation Peptidyl-serine Dephosphorylation Phosphatidylinositol Metabolic Process Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity MAPK Cascade N-terminal Protein Myristoylation ErbB-3 Class Receptor Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Negative Regulation Of Transport Nucleoplasm
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