EPS8L1 and ABI1

Number of citations of the paper that reports this interaction (PMID 14565974)
23

Data Source:
HPRD (in vivo)

		EPS8L1	ABI1
Gene Name		EPS8-like 1	abl-interactor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Ruffle Membrane Protein Complex Extracellular Vesicular Exosome	Intracellular Nucleus Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Cell Junction Filopodium Growth Cone SCAR Complex Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding	Protein Binding Cytoskeletal Protein Binding Protein Tyrosine Kinase Activator Activity Protein Complex Binding
	Biological Process	Rho Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Rac GTPase Activity Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly	Somitogenesis Movement Of Cell Or Subcellular Component Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis
Pathways			Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ABI1 ACTN2 SOS1 TERF2IP	27 interactors: ABL1 APBB1 CACNA1A CYFIP2 ENAH EPS8 EPS8L1 EVL GAS7 HSPA8 MINK1 NCK1 NCK2 NCKAP1 NEB NIN PAK2 PRPF40A SOS1 SOS2 SPTA1 SPTAN1 SRRM1 TCERG1 VASP WASF1 WASF2
Entrez ID		54869	10006
HPRD ID		13276	04336
Ensembl ID		ENSG00000131037	ENSG00000136754
Uniprot IDs		B4DKV7 Q8TE68	B6VEX3 B6VEX4 B6VEX5 Q8IZP0
PDB IDs		2K2M 2ROL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Platelet Activation Cell Projection Organization Response To Stress Fc Receptor Signaling Pathway Lamellipodium Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Microspike Assembly Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Localization To Cell Surface Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Blood Coagulation Hemostasis Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Immune Response-regulating Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Megakaryocyte Development Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Telomere Maintenance Regulation Of Protein Localization To Cell Surface Regulation Of Body Fluid Levels RNA-dependent DNA Replication Wound Healing Negative Regulation Of Potassium Ion Transport Negative Regulation Of DNA Recombination Positive Regulation Of ERBB Signaling Pathway Megakaryocyte Differentiation Actin Filament-based Process Regulation Of Double-strand Break Repair Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Cell Activation Positive Regulation Of Potassium Ion Transport Protein Localization To Chromosome Response To Wounding Telomere Maintenance Via Telomere Lengthening Actin-myosin Filament Sliding Focal Adhesion Assembly Muscle Filament Sliding Regulation Of Signal Transduction Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Potassium Ion Transmembrane Transport Innate Immune Response	Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Differentiation Neuron Development Locomotion Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Axonogenesis Neuron Differentiation Regulation Of Actin Filament-based Process Axon Development Actin Cytoskeleton Organization Chemotaxis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Cytoskeleton Organization Cell Development Actin Filament Organization Generation Of Neurons Neurogenesis Anatomical Structure Morphogenesis Nervous System Development Regulation Of Actin Filament Length Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Immune Response-regulating Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization System Development Rac Protein Signal Transduction Cell Differentiation Fc Receptor Signaling Pathway Multicellular Organismal Development Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Actin Polymerization Or Depolymerization Anatomical Structure Development
Tagcloud ?			aba abl1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding
Tagcloud (Difference) ?			aba abl1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding
Tagcloud (Intersection) ?