EPS8L1 and ACTN2

Number of citations of the paper that reports this interaction (PMID 14565974)
23

Data Source:
HPRD (in vivo)

		EPS8L1	ACTN2
Gene Name		EPS8-like 1	actinin, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Ruffle Membrane Protein Complex Extracellular Vesicular Exosome	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Rho Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Rac GTPase Activity Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways			Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ABI1 ACTN2 SOS1 TERF2IP	59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446
Entrez ID		54869	88
HPRD ID		13276	00019
Ensembl ID		ENSG00000131037	ENSG00000077522
Uniprot IDs		B4DKV7 Q8TE68	B2RCS5 P35609 Q59FD9
PDB IDs		2K2M 2ROL	1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Platelet Activation Cell Projection Organization Response To Stress Fc Receptor Signaling Pathway Lamellipodium Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Microspike Assembly Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Localization To Cell Surface Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Blood Coagulation Hemostasis Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Immune Response-regulating Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Megakaryocyte Development Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Telomere Maintenance Regulation Of Protein Localization To Cell Surface Regulation Of Body Fluid Levels RNA-dependent DNA Replication Wound Healing Negative Regulation Of Potassium Ion Transport Negative Regulation Of DNA Recombination Positive Regulation Of ERBB Signaling Pathway Megakaryocyte Differentiation Actin Filament-based Process Regulation Of Double-strand Break Repair Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Cell Activation Positive Regulation Of Potassium Ion Transport Protein Localization To Chromosome Response To Wounding Telomere Maintenance Via Telomere Lengthening Actin-myosin Filament Sliding Focal Adhesion Assembly Muscle Filament Sliding Regulation Of Signal Transduction Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Potassium Ion Transmembrane Transport Innate Immune Response	Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport
Tagcloud ?			actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?			actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?