EPS8L1 and SOS1

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro)

		EPS8L1	SOS1
Description		EPS8 signaling adaptor L1	SOS Ras/Rac guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Ruffle Membrane Protein-containing Complex Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Neuronal Cell Body Glutamatergic Synapse GTPase Complex
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding T Cell Receptor Binding Cadherin Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Epidermal Growth Factor Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Heterodimerization Activity Molecular Condensate Scaffold Activity
	Biological Process	Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly	B Cell Homeostasis Hair Follicle Development Lymphocyte Homeostasis Response To Ischemia Heart Morphogenesis Cardiac Atrium Morphogenesis Pericardium Morphogenesis Regulation Of Transcription By RNA Polymerase II Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Vitellogenesis Axon Guidance Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Schwann Cell Development Cytokine-mediated Signaling Pathway Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Fc-epsilon Receptor Signaling Pathway T Cell Activation Regulation Of Cell Population Proliferation Regulation Of T Cell Proliferation Myelination Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Blood Vessel Morphogenesis B Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Small GTPase Mediated Signal Transduction Roof Of Mouth Development Eyelid Development In Camera-type Eye Heart Trabecula Morphogenesis Midbrain Morphogenesis Regulation Of Pro-B Cell Differentiation
Pathways			SOS-mediated signalling SOS-mediated signalling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signaling by SCF-KIT Regulation of KIT signaling Signalling to RAS Signalling to RAS GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction NRAGE signals death through JNK GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling SHC-related events triggered by IGF1R SHC-related events triggered by IGF1R Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization GRB2:SOS provides linkage to MAPK signaling for Integrins NCAM signaling for neurite out-growth G alpha (12/13) signalling events Activation of RAC1 Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade MET activates RAS signaling RET signaling Interleukin-15 signaling RAC1 GTPase cycle Activated NTRK2 signals through RAS Erythropoietin activates RAS Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK3 signals through RAS Interleukin receptor SHC signaling FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Potential therapeutics for SARS Signaling by CSF1 (M-CSF) in myeloid cells Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Signaling by LTK
Drugs
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS			Aseptic loosening in total joint arthroplasty ( 31791832) Corticobasal degeneration ( 26077951) Sensorimotor dexterity ( 31596458)
Interacting Genes		7 interacting genes: ABI1 ACTN2 CD3E CYSRT1 SOS1 SRPK2 TERF2IP	56 interacting genes: ABI1 ABI3 ANXA2 ATP6V1E1 BIN1 CAV1 CD19 CD2AP COPS3 CRK CRKL CSF1R EGFR EPS8 EPS8L1 EPS8L2 ERBB2 ERBB3 ESR1 FGFR1 FRS2 FYN GAB1 GRAP GRB2 HCK HDLBP HRAS ITSN1 ITSN2 LAT2 LCK MAPK1 MAPK3 MUC1 NCK1 NCK2 PACSIN1 PACSIN3 PIK3R2 PLCG1 PTPN11 PTPN6 RANBP9 RIT2 RRAS SH3BP5 SH3KBP1 SHC1 SIRPA SNX18 SNX9 SPTAN1 TNIK UBASH3A ZAP70
Entrez ID		54869	6654
HPRD ID		13276	01681
Ensembl ID		ENSG00000131037	ENSG00000115904
Uniprot IDs		Q8TE68	G5E9C8 Q07889
PDB IDs		2K2M 2ROL	1AWE 1BKD 1DBH 1NVU 1NVV 1NVW 1NVX 1Q9C 1XD2 1XD4 1XDV 2II0 3KSY 4NYI 4NYJ 4NYM 4URU 4URV 4URW 4URX 4URY 4URZ 4US0 4US1 4US2 5OVD 5OVE 5OVF 5OVG 5OVH 5OVI 5WFO 5WFP 5WFQ 5WFR 6BVI 6BVJ 6BVK 6BVL 6BVM 6CUO 6CUP 6CUR 6D55 6D56 6D59 6D5E 6D5G 6D5H 6D5J 6D5L 6D5M 6D5V 6D5W 6EPL 6EPM 6EPN 6EPO 6EPP 6F08 6SCM 6SFR 6V94 6V9F 6V9J 6V9L 6V9M 6V9N 6V9O 6Y44 7AVI 7AVL 7AVS 7AVT 7AVU 7AVV 7KFZ 7UKR 7UKS 8BE2 8BE4 8BE5 8BE6 8BE7 8BE8 8BE9 8BEA 8XJJ
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Positive Regulation Of Endocytic Recycling Positive Regulation Of Macromolecule Metabolic Process Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Cytoskeletal Protein Binding Negative Regulation Of Protein Localization To Cell Surface Filopodium Signal Transduction Positive Regulation Of Actin Filament Depolymerization Postsynaptic Actin Cytoskeleton Dendritic Spine Cell Development Channel Activator Activity Plasma Membrane Bounded Cell Projection Organization Anatomical Structure Formation Involved In Morphogenesis Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Cell Projection Organization Developmental Process LIM Domain Binding Positive Regulation Of T Cell Anergy Alpha-beta T Cell Receptor Complex Signal Complex Assembly Positive Regulation Of Tolerance Induction Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Thymic T Cell Selection T Cell Receptor Binding Regulation Of T Cell Proliferation T Cell Tolerance Induction Intracellular Signaling Cassette Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Population Proliferation Regulation Of T Cell Anergy Immune Response-activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Negative Thymic T Cell Selection CD4-positive, Alpha-beta T Cell Proliferation T Cell Anergy Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of T Cell Tolerance Induction Regulation Of Mononuclear Cell Proliferation Gamma-delta T Cell Receptor Complex Cardiac Atrium Morphogenesis	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling Intracellular Signaling Cassette Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Cellular Component Organization Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Positive Regulation Of MAPK Cascade Cell Migration Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway Positive Regulation Of Cellular Component Organization T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune System Process Regulation Of Developmental Process Cell Motility Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Signaling Regulation Of Immune Response Regulation Of Actin Filament-based Process Response To Growth Factor Cytosol Receptor Tyrosine Kinase Binding Schwann Cell Development Cytoplasm Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Endocytosis Regulation Of Anatomical Structure Morphogenesis Cell Development MAPK Cascade
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