EPS8L1 and CD3E

Number of citations of the paper that reports this interaction (PubMedID 17617578)
0

Data Source:
BioGRID (unspecified method)

		EPS8L1	CD3E
Description		EPS8 signaling adaptor L1	CD3 epsilon subunit of T-cell receptor complex
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Ruffle Membrane Protein-containing Complex Extracellular Exosome	Immunological Synapse Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Dendritic Spine Cell Body
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding T Cell Receptor Binding Cadherin Binding	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding
	Biological Process	Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Immune System Process Positive Regulation Of T Cell Anergy T Cell Anergy Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Calcium-mediated Signaling Cerebellum Development T Cell Costimulation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of Smoothened Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation Lymphocyte Activation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Protein-containing Complex Assembly Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1
Drugs			Muromonab Teplizumab Catumaxomab Mosunetuzumab Teclistamab Odronextamab
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)
Interacting Genes		7 interacting genes: ABI1 ACTN2 CD3E CYSRT1 SOS1 SRPK2 TERF2IP	26 interacting genes: ADAM33 BNIP3 CD3D CD3G CD79B CSK EPS8L1 LCK MUC15 NCK1 NCK2 NCL PIK3R1 PKMYT1 POLR1G PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UBASH3A UNC119 ZAP70 ZFPL1
Entrez ID		54869	916
HPRD ID		13276	08923
Ensembl ID		ENSG00000131037	ENSG00000198851
Uniprot IDs		Q8TE68	P07766
PDB IDs		2K2M 2ROL	1A81 1SY6 1XIW 2ROL 5QU2 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8F0L 8JC0 8JCB 8TW4 8TW6 8VY4 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Positive Regulation Of Endocytic Recycling Positive Regulation Of Macromolecule Metabolic Process Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Cytoskeletal Protein Binding Negative Regulation Of Protein Localization To Cell Surface Filopodium Signal Transduction Positive Regulation Of Actin Filament Depolymerization Postsynaptic Actin Cytoskeleton Dendritic Spine Cell Development Channel Activator Activity Plasma Membrane Bounded Cell Projection Organization Anatomical Structure Formation Involved In Morphogenesis Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Cell Projection Organization Developmental Process LIM Domain Binding Positive Regulation Of T Cell Anergy Alpha-beta T Cell Receptor Complex Signal Complex Assembly Positive Regulation Of Tolerance Induction Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Thymic T Cell Selection T Cell Receptor Binding Regulation Of T Cell Proliferation T Cell Tolerance Induction Intracellular Signaling Cassette Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Population Proliferation Regulation Of T Cell Anergy Immune Response-activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Negative Thymic T Cell Selection CD4-positive, Alpha-beta T Cell Proliferation T Cell Anergy Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of T Cell Tolerance Induction Regulation Of Mononuclear Cell Proliferation Gamma-delta T Cell Receptor Complex Cardiac Atrium Morphogenesis	Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Complex Lymphocyte Activation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Leukocyte Activation Regulation Of Immune Response T Cell Activation Cell Activation Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Adaptive Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune Response Lymphocyte Differentiation Alpha-beta T Cell Receptor Complex T Cell Selection Negative Regulation Of T Cell Receptor Signaling Pathway Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Mononuclear Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Thymic T Cell Selection T Cell Receptor Binding Positive T Cell Selection Leukocyte Differentiation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Gamma-delta T Cell Activation T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Beta Selection Immune Response Regulation Of Cell-cell Adhesion B Cell Activation Positive Regulation Of Cell-cell Adhesion
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