EPS8L1

Name	EPS8 signaling adaptor L1
Structure
Interactors	7 interactors: ABI1 ACTN2 CD3E CYSRT1 SOS1 SRPK2 TERF2IP
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Ruffle Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding T Cell Receptor Binding Cadherin Binding
	Biological Process	Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly
GWAS	No GWAS studies recorded
Entrez ID	54869
HPRD ID	13276
Ensembl ID	ENSG00000131037
Uniprot IDs	Q8TE68
PDB IDs	2K2M 2ROL
GO Terms Enriched among Interactors ?	SH3 Domain Binding Positive Regulation Of Endocytic Recycling Positive Regulation Of Macromolecule Metabolic Process Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Cytoskeletal Protein Binding Negative Regulation Of Protein Localization To Cell Surface Filopodium Signal Transduction Positive Regulation Of Actin Filament Depolymerization Postsynaptic Actin Cytoskeleton Dendritic Spine Cell Development Channel Activator Activity Plasma Membrane Bounded Cell Projection Organization Anatomical Structure Formation Involved In Morphogenesis Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Cell Projection Organization Developmental Process LIM Domain Binding Positive Regulation Of T Cell Anergy Alpha-beta T Cell Receptor Complex Signal Complex Assembly Positive Regulation Of Tolerance Induction Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Thymic T Cell Selection T Cell Receptor Binding Regulation Of T Cell Proliferation T Cell Tolerance Induction Intracellular Signaling Cassette Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Population Proliferation Regulation Of T Cell Anergy Immune Response-activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Negative Thymic T Cell Selection CD4-positive, Alpha-beta T Cell Proliferation T Cell Anergy Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of T Cell Tolerance Induction Regulation Of Mononuclear Cell Proliferation Gamma-delta T Cell Receptor Complex Cardiac Atrium Morphogenesis