TRPM7 and PLCG1

Number of citations of the paper that reports this interaction (PubMedID 11941371)
0

Data Source:
HPRD (two hybrid, in vitro)

		TRPM7	PLCG1
Description		transient receptor potential cation channel subfamily M member 7	phospholipase C gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Ruffle Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Lamellipodium Ruffle Membrane Cell Projection
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Zinc Ion Transmembrane Transporter Activity Protein Binding ATP Binding Magnesium Ion Transmembrane Transporter Activity Kinase Activity Transferase Activity Myosin Binding Metal Ion Binding Protein Serine Kinase Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase Binding Metal Ion Binding Calcium-dependent Phospholipase C Activity Phosphatidylinositol Phospholipase C Activity
	Biological Process	Protein Phosphorylation Monoatomic Ion Transport Calcium Ion Transport Zinc Ion Transport Magnesium Ion Homeostasis Intracellular Magnesium Ion Homeostasis Programmed Cell Death Magnesium Ion Transport Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Monoatomic Ion Transmembrane Transport Protein Autophosphorylation Protein Tetramerization Protein Homotetramerization Transmembrane Transport Necroptotic Process Calcium Ion Transmembrane Transport Zinc Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Magnesium Ion Transmembrane Transport	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Cell Migration Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		TRP channels	ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Signaling by ALK Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by ALK fusions and activated point mutants
Drugs		Masoprocol Phosphoaminophosphonic Acid-Adenylate Ester 1,4-Dithiothreitol
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Body composition traits ( 30026463) Calcium levels ( 29403010) Chronic obstructive pulmonary disease ( 30804561) Electrocardiographic traits (multivariate) ( 32602732) Household income (MTAG) ( 31844048) Pulse pressure ( 27841878) QT interval ( 24952745) Systolic blood pressure ( 27841878)	Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Major depressive disorder ( 27479909) Male-pattern baldness ( 28196072) Refractive error ( 32231278) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: ANXA1 EEF2 H3-4 ITSN1 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6	112 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RBM11 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70
Entrez ID		54822	5335
HPRD ID		10418	01398
Ensembl ID		ENSG00000092439	ENSG00000124181
Uniprot IDs		H0YLN8 Q96QT4	P19174
PDB IDs			1HSQ 2HSP 4EY0 4FBN 7NXE
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phosphatidylinositol-mediated Signaling Phosphoric Diester Hydrolase Activity Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol Calcium Ion Transmembrane Transport Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Binding Phosphatidylinositol Metabolic Process Regulation Of Sequestering Of Calcium Ion Glycerophospholipid Metabolic Process Lipid Catabolic Process Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Glycerolipid Metabolic Process Inorganic Ion Transmembrane Transport Phospholipid Metabolic Process Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Postsynaptic Cytosol Calmodulin Binding Intracellular Signal Transduction Transmembrane Transport Phospholipid Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Hormone Secretion Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Cycle G1/S Phase Transition Translation At Postsynapse Positive Regulation Of Metalloendopeptidase Activity G-protein Beta/gamma-subunit Complex Negative Regulation Of Monocyte Extravasation Cellular Response To Glyceraldehyde Phosphatidylinositol Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Growth Factor G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transport Calcium-dependent Phospholipase C Activity Clathrin-dependent Synaptic Vesicle Endocytosis Cellular Response To Fluoride Activation Of Meiosis Involved In Egg Activation Hydrolase Activity Organophosphate Metabolic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Plasma Membrane Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of Signal Transduction Protein Autophosphorylation Positive Regulation Of Signal Transduction Cell Migration Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Receptor Complex Antigen Receptor-mediated Signaling Pathway Cell Motility Activation Of Immune Response Immune System Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway ATP Binding Cell Activation Positive Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Response To Growth Factor Developmental Process Nucleotide Binding Leukocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process
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