TRPM7 and PLCB2

Number of citations of the paper that reports this interaction (PMID 11941371)
121

Data Source:
HPRD (in vitro, two hybrid)

		TRPM7	PLCB2
Gene Name		transient receptor potential cation channel, subfamily M, member 7	phospholipase C, beta 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Plasma Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	Actin Binding Protein Serine/threonine Kinase Activity Calcium Channel Activity ATP Binding Myosin Binding Metal Ion Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding
	Biological Process	Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Ion Transmembrane Transport Protein Autophosphorylation Transmembrane Transport Necroptotic Process Calcium Ion Transmembrane Transport	Phospholipid Metabolic Process Activation Of Phospholipase C Activity Synaptic Transmission Metabolic Process Lipid Catabolic Process Intracellular Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Sensory Perception Of Bitter Taste
Pathways		Ion channel transport TRP channels Stimuli-sensing channels	G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ANXA1 EEF2 HIST3H3 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6	7 interactors: GNAQ MAP2K3 MAP2K6 SLC9A3R1 SNCA TRPC3 TRPM7
Entrez ID		54822	5330
HPRD ID		10418	04985
Ensembl ID		ENSG00000092439	ENSG00000137841
Uniprot IDs		H0YLN8 Q96QT4	Q00722 Q59F77
PDB IDs			2FJU 2ZKM
Enriched GO Terms of Interacting Partners?		Inositol Phosphate Metabolic Process Lipid Catabolic Process Regulation Of Phospholipase Activity Alcohol Metabolic Process Cell-cell Signaling Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Synaptic Transmission Response To Cytokine Activation Of Phospholipase C Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cell Cycle Phase Transition Phospholipid Metabolic Process Positive Regulation Of Phospholipase Activity Organophosphate Metabolic Process Neutrophil Clearance Positive Regulation Of CD24 Biosynthetic Process Interleukin-15-mediated Signaling Pathway Negative Regulation Of Monocyte Extravasation Response To Interleukin-1 Positive Regulation Of Lipase Activity DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Activation Of Meiosis Involved In Egg Activation Lipid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Cytokine Production Regulation Of G1/S Transition Of Mitotic Cell Cycle Defense Response To Nematode Negative Regulation Of Phospholipase A2 Activity Interleukin-12-mediated Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Activation Of Meiosis Negative Regulation Of Interleukin-8 Secretion Response To Interleukin-12 Response To Toxic Substance Phosphate-containing Compound Metabolic Process Positive Regulation Of Transport Prolactin Secretion Positive Regulation Of Acrosome Reaction Positive Regulation Of Prostaglandin Biosynthetic Process Response To Nematode Negative Regulation Of Phospholipase Activity Negative Regulation Of Cytokine Production Regulation Of Fertilization Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Response To Interleukin-15	Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Ion Transport Dopamine Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transporter Activity Regulation Of Cellular Protein Metabolic Process Cardiac Muscle Contraction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Heart Contraction Negative Regulation Of Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Catalytic Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cation Transport Regulation Of Intracellular Transport Regulation Of Calcium Ion Transport Into Cytosol Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Kinase Activity Striated Muscle Contraction Regulation Of Phospholipase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Thrombin Receptor Signaling Pathway Renal Phosphate Ion Absorption Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Positive Regulation Of Transferase Activity Toll-like Receptor Signaling Pathway
Tagcloud ?		abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader magnesium mg2 open optimal provides reading regulating together translation ubiquitous upstream	adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcd1 plce potentiate quiescent react transduction tuned umbilical upcoming
Tagcloud (Difference) ?		abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader magnesium mg2 open optimal provides reading regulating together translation ubiquitous upstream	adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcd1 plce potentiate quiescent react transduction tuned umbilical upcoming
Tagcloud (Intersection) ?