TRPM7 and TRPM6

Number of citations of the paper that reports this interaction (PMID 14976260)
57

Data Source:
HPRD (in vitro, in vivo)

		TRPM7	TRPM6
Gene Name		transient receptor potential cation channel, subfamily M, member 7	transient receptor potential cation channel, subfamily M, member 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane
	Molecular Function	Actin Binding Protein Serine/threonine Kinase Activity Calcium Channel Activity ATP Binding Myosin Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Calcium Channel Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Ion Transmembrane Transport Protein Autophosphorylation Transmembrane Transport Necroptotic Process Calcium Ion Transmembrane Transport	Protein Phosphorylation Response To Toxic Substance Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport
Pathways		Ion channel transport TRP channels Stimuli-sensing channels	Ion channel transport TRP channels Stimuli-sensing channels
Drugs
Diseases
GWAS			Magnesium levels ( 20700443)
Protein-Protein Interactions		9 interactors: ANXA1 EEF2 HIST3H3 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6	1 interactors: TRPM7
Entrez ID		54822	140803
HPRD ID		10418	06112
Ensembl ID		ENSG00000092439	ENSG00000119121
Uniprot IDs		H0YLN8 Q96QT4	Q9BX84
PDB IDs
Enriched GO Terms of Interacting Partners?		Inositol Phosphate Metabolic Process Lipid Catabolic Process Regulation Of Phospholipase Activity Alcohol Metabolic Process Cell-cell Signaling Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Synaptic Transmission Response To Cytokine Activation Of Phospholipase C Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cell Cycle Phase Transition Phospholipid Metabolic Process Positive Regulation Of Phospholipase Activity Organophosphate Metabolic Process Neutrophil Clearance Positive Regulation Of CD24 Biosynthetic Process Interleukin-15-mediated Signaling Pathway Negative Regulation Of Monocyte Extravasation Response To Interleukin-1 Positive Regulation Of Lipase Activity DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Activation Of Meiosis Involved In Egg Activation Lipid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Cytokine Production Regulation Of G1/S Transition Of Mitotic Cell Cycle Defense Response To Nematode Negative Regulation Of Phospholipase A2 Activity Interleukin-12-mediated Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Activation Of Meiosis Negative Regulation Of Interleukin-8 Secretion Response To Interleukin-12 Response To Toxic Substance Phosphate-containing Compound Metabolic Process Positive Regulation Of Transport Prolactin Secretion Positive Regulation Of Acrosome Reaction Positive Regulation Of Prostaglandin Biosynthetic Process Response To Nematode Negative Regulation Of Phospholipase Activity Negative Regulation Of Cytokine Production Regulation Of Fertilization Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Response To Interleukin-15	Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Magnesium Ion Homeostasis Necroptotic Process Programmed Necrotic Cell Death Necrotic Cell Death Actomyosin Structure Organization Cell-matrix Adhesion Protein Autophosphorylation Cell-substrate Adhesion Calcium Ion Transmembrane Transport
Tagcloud ?		abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader magnesium mg2 open optimal provides reading regulating together translation ubiquitous upstream	absorption achieving asthma balance convoluted decipher dysregulation elucidated entry expanded functioning gatekeeper give handling hence hormones hypomagnesemia hypomagnesemic magnesium mal melastatin mellitus osteoporosis overview risks tight tubule view vital
Tagcloud (Difference) ?		abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader mg2 open optimal provides reading regulating together translation ubiquitous upstream	absorption achieving asthma balance convoluted decipher dysregulation elucidated entry expanded functioning gatekeeper give handling hence hormones hypomagnesemia hypomagnesemic mal melastatin mellitus osteoporosis overview risks tight tubule view vital
Tagcloud (Intersection) ?		magnesium