TRPM7 and TRPM6

Number of citations of the paper that reports this interaction (PubMedID 14976260)
26

Data Source:
HPRD (in vitro, in vivo)

		TRPM7	TRPM6
Description		transient receptor potential cation channel subfamily M member 7	transient receptor potential cation channel subfamily M member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Nucleus Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Zinc Ion Transmembrane Transporter Activity Protein Binding ATP Binding Magnesium Ion Transmembrane Transporter Activity Kinase Activity Transferase Activity Myosin Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transporter Activity Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Monoatomic Ion Transport Calcium Ion Transport Zinc Ion Transport Magnesium Ion Homeostasis Intracellular Magnesium Ion Homeostasis Programmed Cell Death Magnesium Ion Transport Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Monoatomic Ion Transmembrane Transport Protein Autophosphorylation Protein Tetramerization Protein Homotetramerization Transmembrane Transport Necroptotic Process Calcium Ion Transmembrane Transport Zinc Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Magnesium Ion Transmembrane Transport	Monoatomic Ion Transport Calcium Ion Transport Response To Toxic Substance Metal Ion Transport Monoatomic Ion Transmembrane Transport Protein Tetramerization Transmembrane Transport Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Magnesium Ion Transmembrane Transport
Pathways		TRP channels	TRP channels
Drugs		Masoprocol Phosphoaminophosphonic Acid-Adenylate Ester 1,4-Dithiothreitol
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Body composition traits ( 30026463) Calcium levels ( 29403010) Chronic obstructive pulmonary disease ( 30804561) Electrocardiographic traits (multivariate) ( 32602732) Household income (MTAG) ( 31844048) Pulse pressure ( 27841878) QT interval ( 24952745) Systolic blood pressure ( 27841878)	Annualised percent change of cerebrospinal fluid AB1-42 levels ( 31370031) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Femur bone mineral density x serum urate levels interaction ( 34046847) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Magnesium levels ( 20700443 26058915) Metabolite levels ( 23823483) Pre-treatment viral load in HIV-1 infection ( 31219150) Prepulse inhibition of the startle response ( 31596458) Urinary magnesium-to-creatinine ratio ( 29093028)
Interacting Genes		10 interacting genes: ANXA1 EEF2 H3-4 ITSN1 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6	1 interacting genes: TRPM7
Entrez ID		54822	140803
HPRD ID		10418	06112
Ensembl ID		ENSG00000092439	ENSG00000119121
Uniprot IDs		H0YLN8 Q96QT4	Q9BX84
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phosphatidylinositol-mediated Signaling Phosphoric Diester Hydrolase Activity Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol Calcium Ion Transmembrane Transport Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Binding Phosphatidylinositol Metabolic Process Regulation Of Sequestering Of Calcium Ion Glycerophospholipid Metabolic Process Lipid Catabolic Process Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Glycerolipid Metabolic Process Inorganic Ion Transmembrane Transport Phospholipid Metabolic Process Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Postsynaptic Cytosol Calmodulin Binding Intracellular Signal Transduction Transmembrane Transport Phospholipid Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Hormone Secretion Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Cycle G1/S Phase Transition Translation At Postsynapse Positive Regulation Of Metalloendopeptidase Activity G-protein Beta/gamma-subunit Complex Negative Regulation Of Monocyte Extravasation Cellular Response To Glyceraldehyde Phosphatidylinositol Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Growth Factor G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transport Calcium-dependent Phospholipase C Activity Clathrin-dependent Synaptic Vesicle Endocytosis Cellular Response To Fluoride Activation Of Meiosis Involved In Egg Activation Hydrolase Activity Organophosphate Metabolic Process	Calcium-dependent Cell-matrix Adhesion Magnesium Ion Transport Magnesium Ion Transmembrane Transporter Activity Programmed Necrotic Cell Death Magnesium Ion Homeostasis Magnesium Ion Transmembrane Transport Zinc Ion Transport Myosin Binding Intracellular Magnesium Ion Homeostasis Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Necroptotic Process Monoatomic Cation Channel Activity Protein Homotetramerization Calcium Channel Activity Protein Tetramerization Ruffle Cell-matrix Adhesion Actomyosin Structure Organization Protein Autophosphorylation Cell-substrate Adhesion Monoatomic Ion Channel Activity Cytoplasmic Vesicle Membrane Protein Homooligomerization Calcium Ion Transmembrane Transport Calcium Ion Transport Protein Complex Oligomerization
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