TRPM7 and EEF2

Number of citations of the paper that reports this interaction (PubMedID 14594813)
0

Data Source:
HPRD (in vitro)

		TRPM7	EEF2
Description		transient receptor potential cation channel subfamily M member 7	eukaryotic translation elongation factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Extracellular Region Nucleus Cytoplasm Cytosol Ribosome Plasma Membrane Membrane Aggresome Secretory Granule Lumen Synapse Extracellular Exosome Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Zinc Ion Transmembrane Transporter Activity Protein Binding ATP Binding Magnesium Ion Transmembrane Transporter Activity Kinase Activity Transferase Activity Myosin Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding P53 Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding 5S RRNA Binding Hydrolase Activity Protein Kinase Binding Ribosome Binding Cadherin Binding Actin Filament Binding LncRNA Binding
	Biological Process	Protein Phosphorylation Monoatomic Ion Transport Calcium Ion Transport Zinc Ion Transport Magnesium Ion Homeostasis Intracellular Magnesium Ion Homeostasis Programmed Cell Death Magnesium Ion Transport Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Monoatomic Ion Transmembrane Transport Protein Autophosphorylation Protein Tetramerization Protein Homotetramerization Transmembrane Transport Necroptotic Process Calcium Ion Transmembrane Transport Zinc Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Magnesium Ion Transmembrane Transport	Hematopoietic Progenitor Cell Differentiation Response To Ischemia Skeletal Muscle Contraction Translation Translational Elongation Response To Xenobiotic Stimulus Glial Cell Proliferation Response To Estradiol Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Response To Hydrogen Peroxide Response To Ethanol Positive Regulation Of Translation Response To Folic Acid Translation At Postsynapse Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Cytoplasmic Translation
Pathways		TRP channels	Peptide chain elongation Peptide chain elongation Uptake and function of diphtheria toxin Synthesis of diphthamide-EEF2 Synthesis of diphthamide-EEF2 Neutrophil degranulation Protein methylation
Drugs		Masoprocol Phosphoaminophosphonic Acid-Adenylate Ester 1,4-Dithiothreitol	Adenosine-5-Diphosphoribose Diphthamide Guanosine-5'-Diphosphate N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Esketamine Moxetumomab pasudotox
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Body composition traits ( 30026463) Calcium levels ( 29403010) Chronic obstructive pulmonary disease ( 30804561) Electrocardiographic traits (multivariate) ( 32602732) Household income (MTAG) ( 31844048) Pulse pressure ( 27841878) QT interval ( 24952745) Systolic blood pressure ( 27841878)
Interacting Genes		10 interacting genes: ANXA1 EEF2 H3-4 ITSN1 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6	28 interacting genes: ANXA1 CDKN2A CEBPA CREBBP DISC1 DSCAM DUX4 EEF2K ESR1 FILNC1 HNRNPD LCOR LINC01554 MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B PTEN RSPH1 RUNX1 SUMO2 TP53 TRPM7 UCHL5 XIAP
Entrez ID		54822	1938
HPRD ID		10418	00561
Ensembl ID		ENSG00000092439	ENSG00000167658
Uniprot IDs		H0YLN8 Q96QT4	P13639
PDB IDs			4V6X 6D9J 6Z6M 6Z6N 8UKB 8XSX 8Y0W 8Y0X
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phosphatidylinositol-mediated Signaling Phosphoric Diester Hydrolase Activity Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol Calcium Ion Transmembrane Transport Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Binding Phosphatidylinositol Metabolic Process Regulation Of Sequestering Of Calcium Ion Glycerophospholipid Metabolic Process Lipid Catabolic Process Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Glycerolipid Metabolic Process Inorganic Ion Transmembrane Transport Phospholipid Metabolic Process Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Postsynaptic Cytosol Calmodulin Binding Intracellular Signal Transduction Transmembrane Transport Phospholipid Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Hormone Secretion Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Cycle G1/S Phase Transition Translation At Postsynapse Positive Regulation Of Metalloendopeptidase Activity G-protein Beta/gamma-subunit Complex Negative Regulation Of Monocyte Extravasation Cellular Response To Glyceraldehyde Phosphatidylinositol Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Growth Factor G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transport Calcium-dependent Phospholipase C Activity Clathrin-dependent Synaptic Vesicle Endocytosis Cellular Response To Fluoride Activation Of Meiosis Involved In Egg Activation Hydrolase Activity Organophosphate Metabolic Process	Regulation Of Proteolysis Regulation Of Cell Cycle Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Transcription Coactivator Binding Protein Phosphatase Type 2A Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Development Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Development Regulation Of Growth Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Developmental Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Metabolic Process Protein Serine/threonine Phosphatase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Cell Differentiation Nucleoplasm Protein Modification Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Estradiol Stimulus Response To Electrical Stimulus Negative Regulation Of Hemopoiesis Positive Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Multicellular Organismal Development Regulation Of Transcription By RNA Polymerase II Rhythmic Process DNA-templated Transcription Histone Deacetylase Binding Regulation Of Macromolecule Biosynthetic Process Organelle Organization Regulation Of Multicellular Organismal Process Transcription Corepressor Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Cytosol
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