TRPM7 and PLCB3

Number of citations: 0 (PubMedID 11941371)
Data Source: BioGRID (pull down)

		TRPM7	PLCB3
Name		transient receptor potential cation channel subfamily M member 7	phospholipase C beta 3
Structure		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Nucleus Cytoplasm Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Zinc Ion Transmembrane Transporter Activity Protein Binding ATP Binding Magnesium Ion Transmembrane Transporter Activity Kinase Activity Transferase Activity Myosin Binding Metal Ion Binding Protein Serine Kinase Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Cadherin Binding Molecular Adaptor Activity Phosphatidylinositol Phospholipase C Activity Molecular Function Activator Activity
	Biological Process	Protein Phosphorylation Monoatomic Ion Transport Calcium Ion Transport Zinc Ion Transport Magnesium Ion Homeostasis Intracellular Magnesium Ion Homeostasis Programmed Cell Death Magnesium Ion Transport Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Monoatomic Ion Transmembrane Transport Protein Autophosphorylation Protein Tetramerization Protein Homotetramerization Transmembrane Transport Necroptotic Process Calcium Ion Transmembrane Transport Zinc Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Magnesium Ion Transmembrane Transport	Regulation Of Systemic Arterial Blood Pressure Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways		TRP channels	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs		Masoprocol Phosphoaminophosphonic Acid-Adenylate Ester 1,4-Dithiothreitol	None
GWAS		Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Body composition traits ( 30026463 ) Calcium levels ( 29403010 ) Chronic obstructive pulmonary disease ( 30804561 ) Electrocardiographic traits (multivariate) ( 32602732 ) Household income (MTAG) ( 31844048 ) Pulse pressure ( 27841878 ) QT interval ( 24952745 ) Systolic blood pressure ( 27841878 )	Crohn's disease ( 28067908 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Vitiligo ( 27723757 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 )
Interacting Genes		10 interacting genes: ANXA1 EEF2 H3-4 ITSN1 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6	13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 NHERF2 PARD3 PARD6A PRKG1 PRKG2 RGS12 TRPC3 TRPM7
Entrez ID		54822	5331
HPRD ID		10418	02577
Ensembl ID		ENSG00000092439	ENSG00000149782
Uniprot IDs		H0YLN8 Q96QT4	Q01970
PDB IDs		Not available	4GNK 4QJ3 4QJ4 4QJ5 7SQ2 8EMV 8EMW 8EMX 8UQN 8UQO
GO Terms Enriched among Interactors		Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phosphatidylinositol-mediated Signaling Phosphoric Diester Hydrolase Activity Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol Calcium Ion Transmembrane Transport Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Binding Phosphatidylinositol Metabolic Process Regulation Of Sequestering Of Calcium Ion Glycerophospholipid Metabolic Process Lipid Catabolic Process Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Glycerolipid Metabolic Process Inorganic Ion Transmembrane Transport Phospholipid Metabolic Process Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Postsynaptic Cytosol Calmodulin Binding Intracellular Signal Transduction Transmembrane Transport Phospholipid Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Hormone Secretion Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Cycle G1/S Phase Transition Translation At Postsynapse Positive Regulation Of Metalloendopeptidase Activity G-protein Beta/gamma-subunit Complex Negative Regulation Of Monocyte Extravasation Cellular Response To Glyceraldehyde Phosphatidylinositol Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Growth Factor G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transport Calcium-dependent Phospholipase C Activity Clathrin-dependent Synaptic Vesicle Endocytosis Cellular Response To Fluoride Activation Of Meiosis Involved In Egg Activation Hydrolase Activity Organophosphate Metabolic Process	Regulation Of Muscle System Process CGMP-dependent Protein Kinase Activity Type 3 Metabotropic Glutamate Receptor Binding Regulation Of System Process Protein Serine Kinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transport Protein Serine/threonine Kinase Activity PAR Polarity Complex Regulation Of Calcium Ion Transport Protein Kinase Activity Regulation Of Skeletal Muscle Adaptation Regulation Of Transport Kinase Activity CGMP Binding Regulation Of Metal Ion Transport Protein Phosphorylation Calcium/calmodulin-dependent Protein Kinase Activity Apical Plasma Membrane Phosphorylation Positive Regulation Of Synaptic Transmission GTPase Regulator Activity Plasma Membrane Tight Junction Sarcoplasmic Reticulum Membrane Regulation Of Synaptic Plasticity Regulation Of Multicellular Organismal Process Localization Within Membrane Regulation Of Cellular Localization Calcium Channel Regulator Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Neuronal Synaptic Plasticity Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Chloride Transport Type 2 Metabotropic Glutamate Receptor Binding Calcium-dependent Cell-matrix Adhesion Calcium Channel Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Chordate Pharynx Development Negative Regulation Of Monoatomic Ion Transport ATP Binding Ruffle Internode Region Of Axon Negative Regulation Of Peptidyl-threonine Phosphorylation