MARCHF5 and AKTIP

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		MARCHF5	AKTIP
Description		membrane associated ring-CH-type finger 5	AKT interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Cytoplasm Plasma Membrane Membrane HOPS Complex FHF Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K27-linked Ubiquitination NLRP3 Inflammasome Complex Assembly Protein Autoubiquitination Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Protein K48-linked Ubiquitination Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Positive Regulation Of Protein Phosphorylation Postreplication Repair Apoptotic Process Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein K63-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Drugs
Diseases
GWAS			Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412 34021172) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		43 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 IMMT MANBAL MAP1B MFN2 ODF4 POLG POLG2 PTPN5 RECQL4 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A	35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS28 VPS41 ZNRF2
Entrez ID		54708	64400
HPRD ID		07909	07467
Ensembl ID		ENSG00000198060	ENSG00000166971
Uniprot IDs		Q9NX47	Q9H8T0
PDB IDs			8QAT
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Mitochondrial Outer Membrane Cellular Response To Stress Gamma DNA Polymerase Complex Protein Ubiquitination Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Protein Binding Post-translational Protein Modification Protein K63-linked Ubiquitination Mitochondrion Organization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Ubiquitin Protein Ligase Binding Nucleotide Binding DNA Repair Apoptotic Process Mitochondrial DNA Replication Mitochondrion Cell Death Programmed Cell Death DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein-containing Complex Regulation Of TOR Signaling TORC1 Signaling DNA Damage Response Protein Autoubiquitination Endoplasmic Reticulum Membrane Endoplasmic Reticulum Response To Stress Mitochondrial DNA Metabolic Process Positive Regulation Of Protein Polyubiquitination Mitochondrial Fusion Ubiquitin-like Protein Transferase Activity Mitochondrial Membrane TOR Signaling DNA-directed DNA Polymerase Activity Proteolysis Involved In Protein Catabolic Process Mitochondrial Calcium Ion Homeostasis Protein Modification Process ATP Binding Protein K6-linked Ubiquitination	HOPS Complex Endosome To Lysosome Transport FHF Complex Intracellular Protein Localization Protein Transport Vacuolar Transport Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Transport Lysosomal Transport Establishment Of Protein Localization Cellular Localization Endosome Organization Intracellular Protein Transport Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Vesicle Organization Lysosome Organization Cytoplasmic Microtubule Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Localization To Organelle Identical Protein Binding Cellular Response To Laminar Fluid Shear Stress Organelle Organization Response To Laminar Fluid Shear Stress Vesicle-mediated Transport Endosomal Transport Endosome Membrane Dynein Light Intermediate Chain Binding CGAS/STING Signaling Pathway Membrane Organization Cellular Response To Fluid Shear Stress Establishment Of Protein Localization To Organelle Ubiquitin Protein Ligase Activity CORVET Complex Response To Fluid Shear Stress Protein Import Into Nucleus Positive Regulation Of CGAS/STING Signaling Pathway Import Into Nucleus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Nuclear Transport Nucleocytoplasmic Transport Protein Ubiquitination AP-3 Adaptor Complex Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Anoikis Microtubule Cytoskeleton Organization Late Endosome Membrane
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