MARCHF5 and MFN2

Number of citations: 22 (PubMedID 16936636)
Data Source: HPRD (in vivo, in vitro)

		MARCHF5	MFN2
Name		membrane associated ring-CH-type finger 5	mitofusin 2
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K27-linked Ubiquitination NLRP3 Inflammasome Complex Assembly Protein Autoubiquitination Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Protein K48-linked Ubiquitination Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Blastocyst Formation Protein Targeting To Mitochondrion Autophagy Apoptotic Process Response To Unfolded Protein Mitochondrion Organization Mitochondrial Membrane Organization Mitochondrial Fusion Aerobic Respiration Protein Localization To Phagophore Assembly Site Negative Regulation Of Ras Protein Signal Transduction Camera-type Eye Morphogenesis Negative Regulation Of Smooth Muscle Cell Proliferation Mitochondrion Localization Type 2 Mitophagy Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		None	PINK1-PRKN Mediated Mitophagy RHOT2 GTPase cycle Factors involved in megakaryocyte development and platelet production
Diseases		None	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		No GWAS studies recorded	Inflammatory skin disease ( 25574825 ) Plasma homocysteine levels ( 30339177 ) Platelet count ( 22139419 32888494 ) Plateletcrit ( 32888494 ) Tuberculosis ( 29036319 )
Interacting Genes		43 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 IMMT MANBAL MAP1B MFN2 ODF4 POLG POLG2 PTPN5 RECQL4 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A	2 interacting genes: MARCHF5 PRKN
Entrez ID		54708	9927
HPRD ID		07909	08495
Ensembl ID		ENSG00000198060	ENSG00000116688
Uniprot IDs		Q9NX47	O95140
PDB IDs		Not available	6JFK 6JFL 6JFM
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Mitochondrial Outer Membrane Cellular Response To Stress Gamma DNA Polymerase Complex Protein Ubiquitination Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Protein Binding Post-translational Protein Modification Protein K63-linked Ubiquitination Mitochondrion Organization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Ubiquitin Protein Ligase Binding Nucleotide Binding DNA Repair Apoptotic Process Mitochondrial DNA Replication Mitochondrion Cell Death Programmed Cell Death DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein-containing Complex Regulation Of TOR Signaling TORC1 Signaling DNA Damage Response Protein Autoubiquitination Endoplasmic Reticulum Membrane Endoplasmic Reticulum Response To Stress Mitochondrial DNA Metabolic Process Positive Regulation Of Protein Polyubiquitination Mitochondrial Fusion Ubiquitin-like Protein Transferase Activity Mitochondrial Membrane TOR Signaling DNA-directed DNA Polymerase Activity Proteolysis Involved In Protein Catabolic Process Mitochondrial Calcium Ion Homeostasis Protein Modification Process ATP Binding Protein K6-linked Ubiquitination	Protein K27-linked Ubiquitination Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Protein Localization To Mitochondrion Protein K63-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Regulation Of Mitochondrion Organization Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrial Outer Membrane Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Protein Polyubiquitination Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Mitochondrion Regulation Of Synaptic Vesicle Transport Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion Regulation Of Retrograde Transport, Endosome To Golgi Ubiquitin Protein Ligase Activity Zinc Ion Binding Response To Dopamine Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To L-glutamate