MARCHF5 and POLG2

Number of citations of the paper that reports this interaction (PubMedID 36136752)
6

Data Source:
BioGRID (enzymatic study)

		MARCHF5	POLG2
Description		membrane associated ring-CH-type finger 5	DNA polymerase gamma 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix Gamma DNA Polymerase Complex Mitochondrial Nucleoid
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity	DNA Binding Double-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding DNA Polymerase Processivity Factor Activity Identical Protein Binding DNA Polymerase Binding
	Biological Process	Protein Polyubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K27-linked Ubiquitination NLRP3 Inflammasome Complex Assembly Protein Autoubiquitination Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Protein K48-linked Ubiquitination Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly	In Utero Embryonic Development DNA Replication DNA-templated DNA Replication Mitochondrial DNA Replication Mitochondrion Organization Mitochondrial DNA Metabolic Process DNA Biosynthetic Process Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways			Transcriptional activation of mitochondrial biogenesis Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases
GWAS			Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		43 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 IMMT MANBAL MAP1B MFN2 ODF4 POLG POLG2 PTPN5 RECQL4 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A	1 interacting genes: MARCHF5
Entrez ID		54708	11232
HPRD ID		07909	09228
Ensembl ID		ENSG00000198060	ENSG00000256525
Uniprot IDs		Q9NX47	E5KS15 Q9UHN1
PDB IDs			2G4C 3IKL 3IKM 4ZTU 4ZTZ 5C51 5C52 5C53 8D33 8D37 8D3R 8D42 8G5I 8G5J 8G5K 8G5L 8G5M 8G5N 8G5O 8G5P 8T7E 8UDK 8UDL 8V54 8V55 8V5R
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Mitochondrial Outer Membrane Cellular Response To Stress Gamma DNA Polymerase Complex Protein Ubiquitination Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Protein Binding Post-translational Protein Modification Protein K63-linked Ubiquitination Mitochondrion Organization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Ubiquitin Protein Ligase Binding Nucleotide Binding DNA Repair Apoptotic Process Mitochondrial DNA Replication Mitochondrion Cell Death Programmed Cell Death DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein-containing Complex Regulation Of TOR Signaling TORC1 Signaling DNA Damage Response Protein Autoubiquitination Endoplasmic Reticulum Membrane Endoplasmic Reticulum Response To Stress Mitochondrial DNA Metabolic Process Positive Regulation Of Protein Polyubiquitination Mitochondrial Fusion Ubiquitin-like Protein Transferase Activity Mitochondrial Membrane TOR Signaling DNA-directed DNA Polymerase Activity Proteolysis Involved In Protein Catabolic Process Mitochondrial Calcium Ion Homeostasis Protein Modification Process ATP Binding Protein K6-linked Ubiquitination	CGAS/STING Signaling Pathway Regulation Of Mitochondrial Fission GTPase Binding Protein K27-linked Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Localization To Mitochondrion Canonical Inflammasome Complex Assembly Positive Regulation Of Mitochondrial Fission NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of CGAS/STING Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Peroxisomal Membrane Protein K63-linked Ubiquitination Protein Autoubiquitination Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K48-linked Ubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Mitochondrion Organization Peroxisome Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?