MARCH5 and FIS1

Number of citations of the paper that reports this interaction (PMID 16874301)
79

Data Source:
HPRD (in vivo)

		MARCH5	FIS1
Gene Name		membrane-associated ring finger (C3HC4) 5	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Mitochondrion Peroxisome Integral Component Of Peroxisomal Membrane Membrane Integral Component Of Mitochondrial Outer Membrane Protein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity GTPase Binding	Receptor Binding Protein Binding
	Biological Process	Protein Polyubiquitination Protein Autoubiquitination Protein Localization To Mitochondrion Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cell Aging	Mitochondrial Fission Mitochondrion Degradation Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: AKTIP FATE1 FIS1 MAP1B MFN2 SOD1 TANK UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN	10 interactors: A2M BCAP31 CCDC155 DNM1L MARCH5 NOS3 PEX5 TBC1D15 UBC VKORC1
Entrez ID		54708	51024
HPRD ID		07909	12352
Ensembl ID		ENSG00000198060	ENSG00000214253
Uniprot IDs		B4DGV8 Q9NX47	Q9Y3D6
PDB IDs			1NZN 1PC2
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Protein Modification Process Immune Response-regulating Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Proteolysis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Immune Response Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Mitochondrial Fusion Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cellular Protein Metabolic Process Response To Stress Regulation Of Immune System Process Innate Immune Response Regulation Of Immune Response	Positive Regulation Of Mitochondrial Fission Cellular Localization Regulation Of Mitochondrial Fission Protein Localization To Organelle Regulation Of Protein Oligomerization Peroxisome Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Protein Localization To Mitochondrion Execution Phase Of Apoptosis Chromosome Localization To Nuclear Envelope Involved In Synapsis Mitochondrial Membrane Fission Dynamin Polymerization Involved In Mitochondrial Fission Oogenesis Mitochondrion Organization Blood Coagulation Regulation Of Signaling Hemostasis Regulation Of Mitochondrion Organization Establishment Of Localization In Cell Negative Regulation Of Protein Homotetramerization Smooth Muscle Hyperplasia Negative Regulation Of Complement Activation, Lectin Pathway Protein Tetramerization Female Gamete Generation Spermatogenesis Male Gamete Generation Regulation Of Peroxisome Organization Protein Import Into Peroxisome Matrix, Translocation Regulation Of Body Fluid Levels Second-messenger-mediated Signaling Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Programmed Cell Death Cellular Protein Localization Smooth Muscle Adaptation Protein Import Into Peroxisome Matrix, Docking Wound Healing Positive Regulation Of Cell Death Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Intrinsic Apoptotic Signaling Pathway Gamete Generation Negative Regulation Of Muscle Hyperplasia Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Apoptotic Process Protein Polyubiquitination Regulation Of Proteolysis
Tagcloud ?			app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fission injected mfn1 mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle
Tagcloud (Difference) ?			app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fission injected mfn1 mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle
Tagcloud (Intersection) ?