MARCHF5 and SGPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MARCHF5	SGPL1
Description		membrane associated ring-CH-type finger 5	sphingosine-1-phosphate lyase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity	Protein Binding Sphinganine-1-phosphate Aldolase Activity Lyase Activity Carbon-carbon Lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Protein Polyubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K27-linked Ubiquitination NLRP3 Inflammasome Complex Assembly Protein Autoubiquitination Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Protein K48-linked Ubiquitination Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Luteinization Vasculogenesis Kidney Development Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Apoptotic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Fibroblast Migration Carboxylic Acid Metabolic Process Hemopoiesis Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway
Pathways			Sphingolipid catabolism
Drugs			Pyridoxal phosphate
Diseases
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		43 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 IMMT MANBAL MAP1B MFN2 ODF4 POLG POLG2 PTPN5 RECQL4 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A	34 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TSPAN4 UNC50
Entrez ID		54708	8879
HPRD ID		07909	07224
Ensembl ID		ENSG00000198060	ENSG00000166224
Uniprot IDs		Q9NX47	A0A8V8TN35 O95470
PDB IDs			4Q6R 8AYF
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Mitochondrial Outer Membrane Cellular Response To Stress Gamma DNA Polymerase Complex Protein Ubiquitination Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Protein Binding Post-translational Protein Modification Protein K63-linked Ubiquitination Mitochondrion Organization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Ubiquitin Protein Ligase Binding Nucleotide Binding DNA Repair Apoptotic Process Mitochondrial DNA Replication Mitochondrion Cell Death Programmed Cell Death DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein-containing Complex Regulation Of TOR Signaling TORC1 Signaling DNA Damage Response Protein Autoubiquitination Endoplasmic Reticulum Membrane Endoplasmic Reticulum Response To Stress Mitochondrial DNA Metabolic Process Positive Regulation Of Protein Polyubiquitination Mitochondrial Fusion Ubiquitin-like Protein Transferase Activity Mitochondrial Membrane TOR Signaling DNA-directed DNA Polymerase Activity Proteolysis Involved In Protein Catabolic Process Mitochondrial Calcium Ion Homeostasis Protein Modification Process ATP Binding Protein K6-linked Ubiquitination	Membrane Channel Activity Water Channel Activity Water Transport Plasma Membrane Glycerol Channel Activity Fluid Transport Urea Transmembrane Transporter Activity Glycerol Transmembrane Transport Basolateral Plasma Membrane Polyol Transmembrane Transport Urea Transmembrane Transport R-loop Processing Positive Regulation Of CGAS/STING Signaling Pathway Urea Transport
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