MARCHF5 and BIK

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MARCHF5	BIK
Name		membrane associated ring-CH-type finger 5	BCL2 interacting killer
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Mitochondrion Endomembrane System Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K27-linked Ubiquitination NLRP3 Inflammasome Complex Assembly Protein Autoubiquitination Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Protein K48-linked Ubiquitination Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria
GWAS		No GWAS studies recorded	Prostate cancer ( 21743057 25939597 ) Prostate cancer (SNP x SNP interaction) ( 22219177 )
Interacting Genes		43 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 IMMT MANBAL MAP1B MFN2 ODF4 POLG POLG2 PTPN5 RECQL4 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A	116 interacting genes: ADGRE2 ADIPOQ AIG1 ALG8 ANKRD46 APOD APP ARLN ASB11 ATP13A1 BCL2 BCL2A1 BCL2L1 BCL2L2 BET1 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C3orf52 CD53 CD72 CDS2 CLDN19 CMTM5 CMTM7 CNIH1 CNIH3 CREB3 CRKL CTXN3 CXCL16 CYB561 CYB561D2 CYB5B ELOVL4 ERGIC3 EXOC3L2 FAM209A FAM241B FAM3C FATE1 FCGR1A FKBP8 GOSR2 GPX8 GRM2 HMOX2 IGFBP5 INSIG2 KCNN4 LNPEP MARCHF5 MCL1 MS4A13 NAT8 NR2F2 NRM ORMDL1 ORMDL2 PBX3 PEX16 PGAP2 PGRMC1 PLLP PLN PLP1 PLP2 PLPP4 PMP22 REEP4 REEP6 RUSF1 S100A1 SCAMP4 SEC22A SELENOK SERP1 SERP2 SLC35E3 SLC37A4 SLC39A7 SMIM1 SOCS3 STRIT1 STX8 SYNGR1 TANK TMBIM1 TMEM107 TMEM11 TMEM147 TMEM14B TMEM14C TMEM222 TMEM229B TMEM243 TMEM254 TMEM60 TMEM80 TMEM86B TMEM97 TRARG1 TSPO2 UBIAD1 UPK1B VAMP3 VAMP4 VAMP5 VAPA VAPB VMA12 VTI1B YIPF4 ZFPL1
Entrez ID		54708	638
HPRD ID		07909	04547
Ensembl ID		ENSG00000198060	ENSG00000100290
Uniprot IDs		Q9NX47	Q13323
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Mitochondrial Outer Membrane Cellular Response To Stress Gamma DNA Polymerase Complex Protein Ubiquitination Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Protein Binding Post-translational Protein Modification Protein K63-linked Ubiquitination Mitochondrion Organization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Ubiquitin Protein Ligase Binding Nucleotide Binding DNA Repair Apoptotic Process Mitochondrial DNA Replication Mitochondrion Cell Death Programmed Cell Death DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein-containing Complex Regulation Of TOR Signaling TORC1 Signaling DNA Damage Response Protein Autoubiquitination Endoplasmic Reticulum Membrane Endoplasmic Reticulum Response To Stress Mitochondrial DNA Metabolic Process Positive Regulation Of Protein Polyubiquitination Mitochondrial Fusion Ubiquitin-like Protein Transferase Activity Mitochondrial Membrane TOR Signaling DNA-directed DNA Polymerase Activity Proteolysis Involved In Protein Catabolic Process Mitochondrial Calcium Ion Homeostasis Protein Modification Process ATP Binding Protein K6-linked Ubiquitination	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Organelle Fusion Protein Binding Membrane Organization Mitochondrial Outer Membrane SNAP Receptor Activity Bcl-2 Family Protein Complex Release Of Cytochrome C From Mitochondria SNARE Complex Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Fusion Vesicle Organization Endomembrane System Regulation Of Cellular Localization Golgi Vesicle Transport Chemical Homeostasis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Vesicle Fusion BH3 Domain Binding Apoptotic Mitochondrial Changes Organelle Membrane Fusion Cellular Homeostasis Channel Activity Vesicle Fusion With Golgi Apparatus Intracellular Chemical Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Docking Pigment Metabolic Process Presynaptic Endosome Membrane Intracellular Monoatomic Cation Homeostasis Response To Cytokine Heme Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Intracellular Monoatomic Ion Homeostasis Response To Peptide Regulation Of Transport Homeostatic Process Inorganic Ion Homeostasis Dendritic Cell Apoptotic Process Ascorbate Homeostasis FFAT Motif Binding Oxysterol Binding Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Localization