FBXL19 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBXL19	SORBS3
Description		F-box and leucine rich repeat protein 19	sorbin and SH3 domain containing 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction
	Molecular Function	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878 28135244) Mean corpuscular volume ( 27863252) Psoriasis ( 20953189 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Pulse pressure ( 27841878)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		12 interacting genes: ABI1 ABI2 CBFA2T2 CREBBP DGAT2L6 EFHC2 NCK2 RPRM SORBS3 TMEM239 TRIM27 TRIM29	137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414
Entrez ID		54620	10174
HPRD ID		12366	11535
Ensembl ID		ENSG00000099364	ENSG00000120896
Uniprot IDs		H3BPZ0 H3BVB1 Q6PCT2	O60504
PDB IDs		6ASB	2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Actin Filament Organization Actin Filament Organization Signaling Adaptor Activity SCAR Complex Actin-based Cell Projection Positive Regulation Of Actin Nucleation Filopodium Tip Regulation Of Actin Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cytoskeletal Anchor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Actin Nucleation Supramolecular Fiber Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Lamellipodium Organization Positive Regulation Of Cellular Component Organization Actin Polymerization Or Depolymerization P53 Binding Histone H3K27 Acetyltransferase Activity Filopodium Zonula Adherens Assembly Negative Regulation Of Macromolecule Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Acylglycerol Acyl-chain Remodeling Negative Regulation Of Biosynthetic Process Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress SH3 Domain Binding Diacylglycerol O-acyltransferase Activity Regulation Of Neuron Projection Development MRF Binding Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress	Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?